Literature DB >> 16168310

Vesicants.

John McManus1, Kermit Huebner.   

Abstract

Vesicants (or blister agents) are cytotoxic alkylating compounds, which are chemical agents sometimes collectively known as mustard gas or simply as mustard. Other blister agents are nitrogen mustard; sulfur mustard; lewisite, a vesicant that contains arsenic; and phosgene oxime, a halogenated oxime that possesses different properties and toxicity from the other agents. This article discusses history, toxicity, clinical presentation, and common treatment for vesicants.

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Year:  2005        PMID： 16168310     DOI： 10.1016/j.ccc.2005.06.005

Source DB:  PubMed          Journal:  Crit Care Clin        ISSN： 0749-0704            Impact factor:   3.598


  10 in total

1.  Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage.

Authors:  Laurie B Joseph; Donald R Gerecke; Diane E Heck; Adrienne T Black; Patrick J Sinko; Jessica A Cervelli; Robert P Casillas; Michael C Babin; Debra L Laskin; Jeffrey D Laskin
Journal:  Exp Mol Pathol       Date:  2011-06-13       Impact factor: 3.362

2.  Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries.

Authors:  Anil K Jain; Neera Tewari-Singh; Swetha Inturi; David J Orlicky; Carl W White; Rajesh Agarwal
Journal:  Toxicology       Date:  2014-03-12       Impact factor: 4.221

Review 3.  Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite.

Authors:  Dinesh Giri Goswami; Rajesh Agarwal; Neera Tewari-Singh
Journal:  Toxicol Lett       Date:  2017-11-12       Impact factor: 4.372

4.  Cutaneous exposure to lewisite causes acute kidney injury by invoking DNA damage and autophagic response.

Authors:  Ritesh K Srivastava; Amie M Traylor; Changzhao Li; Wenguang Feng; Lingling Guo; Veena B Antony; Trenton R Schoeb; Anupam Agarwal; Mohammad Athar
Journal:  Am J Physiol Renal Physiol       Date:  2018-01-17

5.  Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals.

Authors:  Marina Fosso Yatchang; Bini Mathew; Ritesh K Srivastava; Jasim Khan; Suhail Muzaffar; Sixue Zhang; Mousheng Wu; Ling Zhai; Pedro Ruiz; Anupam Agarwal; James R Bostwick; Mark J Suto; Mohammad Athar; Corinne E Augelli-Szafran
Journal:  Bioorg Med Chem Lett       Date:  2022-03-19       Impact factor: 2.940

6.  Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation.

Authors:  Vasanthi R Sunil; Kinal N Vayas; Jessica A Cervelli; Rama Malaviya; LeRoy Hall; Christopher B Massa; Andrew J Gow; Jeffrey D Laskin; Debra L Laskin
Journal:  Exp Mol Pathol       Date:  2014-06-02       Impact factor: 3.362

7.  Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice.

Authors:  Anil K Jain; Neera Tewari-Singh; Swetha Inturi; David J Orlicky; Carl W White; Rajesh Agarwal
Journal:  Exp Toxicol Pathol       Date:  2013-12-25

8.  Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype.

Authors:  Ritesh K Srivastava; Changzhao Li; Zhiping Weng; Anupam Agarwal; Craig A Elmets; Farrukh Afaq; Mohammad Athar
Journal:  Sci Rep       Date:  2016-10-11       Impact factor: 4.379

9.  Combination of ebselen and hydrocortisone substantially reduces nitrogen mustard-induced cutaneous injury.

Authors:  Hemanta C Rao Tumu; Benedette J Cuffari; Blase Billack
Journal:  Curr Res Toxicol       Date:  2021-10-21

10.  Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals.

Authors:  Ritesh K Srivastava; Suhail Muzaffar; Jasim Khan; Amie M Traylor; Jaroslaw W Zmijewski; Lisa M Curtis; James F George; Aftab Ahmad; Veena B Antony; Anupam Agarwal; Mohammad Athar
Journal:  Ann N Y Acad Sci       Date:  2020-09-03       Impact factor: 6.499
  10 in total

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