Literature DB >> 16167349

NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice.

Hoyun Lee1, Luc Chouinard, Michel Bonin, Robin N Michel.   

Abstract

The nuclear transcription factor of activated T cells (NFAT) suggested to be a tumor suppressor. Here we report that two out of three NFATc3-/- and two in four NFATc3 +/- female mice developed aggressive mammary adenocarcinoma by 12.5 and 16 mo of age, respectively, with no occurrences in age-matched wild-type littermates (N-14). Thus, our data suggest that NFATc3 can suppress the development of mammary gland tumors in female mice. Copyright 2005 Wiley-Liss, Inc

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Year:  2005        PMID： 16167349     DOI： 10.1002/mc.20136

Source DB:  PubMed          Journal:  Mol Carcinog        ISSN： 0899-1987            Impact factor:   4.784


  5 in total

1.  Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

Authors:  Nenggang Zhang; Gouquing Ge; Rene Meyer; Sumita Sethi; Dipanjan Basu; Subhashree Pradhan; Yi-Jue Zhao; Xiao-Nan Li; Wei-Wen Cai; Adel K El-Naggar; Veerabhadran Baladandayuthapani; Frances S Kittrell; Pulivarthi H Rao; Daniel Medina; Debananda Pati
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-26       Impact factor: 11.205

2.  Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells.

Authors:  Yuning Zhou; Qingding Wang; Zheng Guo; Heidi L Weiss; B Mark Evers
Journal:  Mol Biol Cell       Date:  2012-06-13       Impact factor: 4.138

3.  NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription.

Authors:  Xiaobin Zao; Jin Cheng; Congle Shen; Guiwen Guan; Xiaoyu Feng; Jun Zou; Jing Zhang; Tianxu Liu; Huiling Zheng; Ting Zhang; Jie Wang; Jia Liu; Deyao Li; Fengmin Lu; Fuping You; Xiangmei Chen
Journal:  Oncoimmunology       Date:  2021-01-11       Impact factor: 8.110

4.  Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.

Authors:  Anthony G Uren; Jaap Kool; Konstantin Matentzoglu; Jeroen de Ridder; Jenny Mattison; Miranda van Uitert; Wendy Lagcher; Daoud Sie; Ellen Tanger; Tony Cox; Marcel Reinders; Tim J Hubbard; Jane Rogers; Jos Jonkers; Lodewyk Wessels; David J Adams; Maarten van Lohuizen; Anton Berns
Journal:  Cell       Date:  2008-05-16       Impact factor: 41.582

5.  Expression, Prognosis and Gene Regulation Network of NFAT Transcription Factors in Non-Small Cell Lung Cancer.

Authors:  Jin Ma; Rao Du; Yan Huang; Wen Zhong; Huan Gui; Chenmei Mao; Xiudao Song; Jun Lu
Journal:  Pathol Oncol Res       Date:  2021-04-09       Impact factor: 3.201
  5 in total

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