BACKGROUND AND PURPOSE: We report a modified 4-vessel occlusion (4VO) rat model. METHOD: We used a 1-stage anterior approach for making bilateral hemispheric ischemia. RESULTS: Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels. CONCLUSIONS: This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes.
BACKGROUND AND PURPOSE: We report a modified 4-vessel occlusion (4VO) rat model. METHOD: We used a 1-stage anterior approach for making bilateral hemispheric ischemia. RESULTS: Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels. CONCLUSIONS: This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes.
Authors: Paul R Krafft; Emma L Bailey; Tim Lekic; William B Rolland; Orhan Altay; Jiping Tang; Joanna M Wardlaw; John H Zhang; Cathie L M Sudlow Journal: Int J Stroke Date: 2012-07 Impact factor: 5.266
Authors: Robert P Ostrowski; Gerhart Graupner; Elena Titova; Jennifer Zhang; Jeffrey Chiu; Neal Dach; Dalia Corleone; Jiping Tang; John H Zhang Journal: Neurobiol Dis Date: 2007-07-28 Impact factor: 5.996