PURPOSE: The aim of this study was to examine the expression and prognostic relevance of thrombospondin-1 (TSP-1) in tumor biopsies taken from a consecutive series of liver resections done at the University Hospitals of Leicester and the Royal Liverpool Hospital. EXPERIMENTAL DESIGN: Patients having undergone a liver resection for colorectal liver metastases at our institutions between 1993 and 1999 inclusive were eligible. Inclusion criteria were curative intent, sufficient tumor biopsy, and patient follow-up data. One hundred eighty-two patients were considered in this study. Standard immunohistochemical techniques were used to study the expression of TSP-1 in 5-microm tumor sections from paraffin-embedded tissue blocks. TSP-1 was correlated with survival using the Kaplan-Meier method and log-rank test for univariate analysis and the Cox proportional hazard model for multivariate analysis. RESULTS: One hundred eighty-two patients (male, n = 122 and female, n = 60) ages between 25 and 81 years (mean, 61 years) were included. TSP-1 was expressed around blood vessels (n = 45, 25%) or in the stroma (n = 59, 33%). No expression was detected in the remaining tumors. TSP-1 significantly correlated with poor survival on univariate (P = 0.01 for perivascular expression and P = 0.03 for stromal expression) and multivariate analysis (P = 0.01 for perivascular expression). CONCLUSION: TSP-1 is a negatively prognostic factor for survival in resected colorectal liver metastases.
PURPOSE: The aim of this study was to examine the expression and prognostic relevance of thrombospondin-1 (TSP-1) in tumor biopsies taken from a consecutive series of liver resections done at the University Hospitals of Leicester and the Royal Liverpool Hospital. EXPERIMENTAL DESIGN:Patients having undergone a liver resection for colorectal liver metastases at our institutions between 1993 and 1999 inclusive were eligible. Inclusion criteria were curative intent, sufficient tumor biopsy, and patient follow-up data. One hundred eighty-two patients were considered in this study. Standard immunohistochemical techniques were used to study the expression of TSP-1 in 5-microm tumor sections from paraffin-embedded tissue blocks. TSP-1 was correlated with survival using the Kaplan-Meier method and log-rank test for univariate analysis and the Cox proportional hazard model for multivariate analysis. RESULTS: One hundred eighty-two patients (male, n = 122 and female, n = 60) ages between 25 and 81 years (mean, 61 years) were included. TSP-1 was expressed around blood vessels (n = 45, 25%) or in the stroma (n = 59, 33%). No expression was detected in the remaining tumors. TSP-1 significantly correlated with poor survival on univariate (P = 0.01 for perivascular expression and P = 0.03 for stromal expression) and multivariate analysis (P = 0.01 for perivascular expression). CONCLUSION:TSP-1 is a negatively prognostic factor for survival in resected colorectal liver metastases.
Authors: Jorge Barriuso; Raghavendar T Nagaraju; Shreya Belgamwar; Bipasha Chakrabarty; George J Burghel; Helene Schlecht; Lucy Foster; Elaine Kilgour; Andrew J Wallace; Michael Braun; Caroline Dive; D Gareth Evans; Robert G Bristow; Mark P Saunders; Sarah T O'Dwyer; Omer Aziz Journal: Clin Cancer Res Date: 2020-11-30 Impact factor: 12.531
Authors: Seung-Beom Hong; HyoungBin Oh; Vladimir A Valera; Jaime Stull; Duy-Tan Ngo; Masaya Baba; Maria J Merino; W Marston Linehan; Laura S Schmidt Journal: Mol Cancer Date: 2010-06-23 Impact factor: 27.401
Authors: F Loupakis; C Cremolini; A Fioravanti; P Orlandi; L Salvatore; G Masi; T Di Desidero; B Canu; M Schirripa; P Frumento; A Di Paolo; R Danesi; A Falcone; G Bocci Journal: Br J Cancer Date: 2011-03-15 Impact factor: 7.640