Paul B Rosenberg1, Michelle M Mielke, Constantine G Lyketsos. 1. Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, 550 N. Broadway #308, Baltimore, MD 21205, USA. prosenb9@jhmi.edu
Abstract
OBJECTIVE: Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input. METHODS: In a 12-week, controlled, clinical trial of sertraline in depressed AD patients, authors correlated caregiver mood and subjective burden on several patient mood measures, incorporating varied degrees of caregiver input. RESULTS: Caregiver variables accounted for up to 33% of the variance in patient mood ratings. Caregiver depression and burden decreased regardless of treatment assignment. CONCLUSION:Caregiver depression and burden affect their rating of AD patients' mood, but the majority of variance is due to patient characteristics.
RCT Entities:
OBJECTIVE: Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input. METHODS: In a 12-week, controlled, clinical trial of sertraline in depressed ADpatients, authors correlated caregiver mood and subjective burden on several patient mood measures, incorporating varied degrees of caregiver input. RESULTS: Caregiver variables accounted for up to 33% of the variance in patient mood ratings. Caregiver depression and burden decreased regardless of treatment assignment. CONCLUSION: Caregiver depression and burden affect their rating of ADpatients' mood, but the majority of variance is due to patient characteristics.
Authors: Laurel D Pellegrino; Matthew E Peters; Constantine G Lyketsos; Christopher M Marano Journal: Curr Psychiatry Rep Date: 2013-09 Impact factor: 5.285
Authors: Crystal V Flynn Longmire; Lea T Drye; Constantine E Frangakis; Barbara K Martin; Curtis L Meinert; Jacobo E Mintzer; Cynthia A Munro; Anton P Porsteinsson; Peter V Rabins; Paul B Rosenberg; Lon S Schneider; Daniel Weintraub; Constantine G Lyketsos Journal: Am J Geriatr Psychiatry Date: 2014-01 Impact factor: 4.105
Authors: Paul B Rosenberg; Lea T Drye; Anton P Porsteinsson; Bruce G Pollock; D P Devanand; Constantine Frangakis; Zahinoor Ismail; Christopher Marano; Curtis L Meinert; Jacobo E Mintzer; Cynthia A Munro; Gregory Pelton; Peter V Rabins; Lon S Schneider; David M Shade; Daniel Weintraub; Jeffery Newell; Jerome Yesavage; Constantine G Lyketsos Journal: Int Psychogeriatr Date: 2015-08-25 Impact factor: 3.878
Authors: Florindo Stella; Orestes Vicente Forlenza; Jerson Laks; Larissa Pires de Andrade; Michelle A Ljubetic Avendaño; Elisandra Villela Gasparetto Sé; João de Castilho Cação; Constantine G Lyketsos; Kate de Medeiros Journal: Int Psychogeriatr Date: 2013-06-14 Impact factor: 3.878
Authors: M Sano; M Soto; M Carrillo; J Cummings; S Hendrix; J Mintzer; A Porsteinsson; P Rosenberg; L Schneider; J Touchon; P Aisen; B Vellas; C Lyketsos Journal: J Prev Alzheimers Dis Date: 2018