OBJECTIVE: Personality disorders (PDs) have been associated with poor treatment outcomes in acute treatments for late-life depression and with persistent functional impairment after recovery from an episode of depression. METHODS: Using survival analysis and mixed-effects models, the authors examined the impact of Cluster C PDs on time-to-response and several aspects of functioning in acute and maintenance treatment of major depression in later life. RESULTS: Cluster C PDs were associated with longer time-to-response during acute treatment and non-response in continuation or maintenance treatment. Although not statistically significant, there was evidence of a cumulative negative impact of Cluster C PDs and residual depressive symptoms on instrumental activities of daily living (IADLs) during maintenance treatment. CONCLUSIONS: These findings suggest that screening for PD may be important for clinicians treating late-life depression and that the combination of Cluster C PDs and residual depressive symptoms may predict functional declines even after recovery from the index episode of depression.
RCT Entities:
OBJECTIVE: Personality disorders (PDs) have been associated with poor treatment outcomes in acute treatments for late-life depression and with persistent functional impairment after recovery from an episode of depression. METHODS: Using survival analysis and mixed-effects models, the authors examined the impact of Cluster C PDs on time-to-response and several aspects of functioning in acute and maintenance treatment of major depression in later life. RESULTS:Cluster C PDs were associated with longer time-to-response during acute treatment and non-response in continuation or maintenance treatment. Although not statistically significant, there was evidence of a cumulative negative impact of Cluster C PDs and residual depressive symptoms on instrumental activities of daily living (IADLs) during maintenance treatment. CONCLUSIONS: These findings suggest that screening for PD may be important for clinicians treating late-life depression and that the combination of Cluster C PDs and residual depressive symptoms may predict functional declines even after recovery from the index episode of depression.
Authors: S P J van Alphen; S D M van Dijk; A C Videler; G Rossi; E Dierckx; F Bouckaert; R C Oude Voshaar Journal: Curr Psychiatry Rep Date: 2015-01 Impact factor: 5.285
Authors: Alexandre Y Dombrovski; Benoit H Mulsant; Patricia R Houck; Sati Mazumdar; Eric J Lenze; Carmen Andreescu; Jill M Cyranowski; Charles F Reynolds Journal: J Affect Disord Date: 2007-02-26 Impact factor: 4.839
Authors: Merit P George; Gregory M Garrison; Zachary Merten; Dagoberto Heredia; Cesar Gonzales; Kurt B Angstman Journal: J Prim Care Community Health Date: 2018 Jan-Dec
Authors: Carlos Roncero; Adelia de Miguel; Ascensión Fumero; Alfonso C Abad; Rita Martín; Juan Manuel Bethencourt; Lara Grau-López; Laia Rodríguez-Cintas; Constanza Daigre Journal: Front Psychiatry Date: 2018-02-08 Impact factor: 4.157