Literature DB >> 16165349

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

Lori Krim Gavrin1, Neal Green, Yonghan Hu, Kristin Janz, Neelu Kaila, Huan-Qiu Li, Steve Y Tam, Jennifer R Thomason, Ariamala Gopalsamy, Greg Ciszewski, John W Cuozzo, J Perry Hall, Sang Hsu, Jean-Baptiste Telliez, Lih-Ling Lin.   

Abstract

The synthesis and structure-activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early exploratory work described here may lead to the discovery of compounds with significant therapeutic potential for treating rheumatoid arthritis and other inflammatory diseases.

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Year:  2005        PMID： 16165349     DOI： 10.1016/j.bmcl.2005.08.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  19 in total

1.  Tpl2/AP-1 enhances murine gammaherpesvirus 68 lytic replication.

Authors:  Xudong Li; Jun Feng; Shijia Chen; Li Peng; Wei-Wu He; Jing Qi; Hongyu Deng; Ren Sun
Journal:  J Virol       Date:  2009-11-25       Impact factor: 5.103

2.  MicroRNA 375 mediates the signaling pathway of corticotropin-releasing factor (CRF) regulating pro-opiomelanocortin (POMC) expression by targeting mitogen-activated protein kinase 8.

Authors:  Nan Zhang; Jun-kai Lin; Juan Chen; Xiong-fei Liu; Jia-li Liu; Hao-shu Luo; Yue-qin Li; Sheng Cui
Journal:  J Biol Chem       Date:  2013-02-21       Impact factor: 5.157

3.  Effect on tumor necrosis factor-α production and antioxidant ability of black alder, as factors related to its anti-inflammatory properties.

Authors:  Nuria Acero; Dolores Muñoz-Mingarro
Journal:  J Med Food       Date:  2012-03-16       Impact factor: 2.786

4.  TPL2 enforces RAS-induced inflammatory signaling and is activated by point mutations.

Authors:  Paarth B Dodhiawala; Namrata Khurana; Daoxiang Zhang; Yi Cheng; Lin Li; Qing Wei; Kuljeet Seehra; Hongmei Jiang; Patrick M Grierson; Andrea Wang-Gillam; Kian-Huat Lim
Journal:  J Clin Invest       Date:  2020-09-01       Impact factor: 14.808

5.  The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.

Authors:  Flavien Berthou; Franck Ceppo; Karine Dumas; Fabienne Massa; Bastien Vergoni; Susana Alemany; Mireille Cormont; Jean-François Tanti
Journal:  Mol Endocrinol       Date:  2015-05-28

6.  Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum.

Authors:  Ying Liu; Yueqin Li; Di Zhang; Jiali Liu; Kemian Gou; Sheng Cui
Journal:  Mol Endocrinol       Date:  2015-03-12

7.  The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.

Authors:  Sascha Gutmann; Alexandra Hinniger; Gabriele Fendrich; Peter Drückes; Sylvie Antz; Henri Mattes; Henrik Möbitz; Silvio Ofner; Niko Schmiedeberg; Aleksandar Stojanovic; Sebastien Rieffel; André Strauss; Thomas Troxler; Ralf Glatthar; Helmut Sparrer
Journal:  J Biol Chem       Date:  2015-04-27       Impact factor: 5.157

8.  Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

Authors:  Lisa A Mielke; Karen L Elkins; Lai Wei; Robyn Starr; Philip N Tsichlis; John J O'Shea; Wendy T Watford
Journal:  J Immunol       Date:  2009-12-15       Impact factor: 5.422

9.  Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity.

Authors:  Hong Seok Choi; Bong Seok Kang; Jung-Hyun Shim; Yong-Yeon Cho; Bu Young Choi; Ann M Bode; Zigang Dong
Journal:  FASEB J       Date:  2007-08-27       Impact factor: 5.191

10.  Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.

Authors:  Jennifer Jager; Thierry Grémeaux; Teresa Gonzalez; Stéphanie Bonnafous; Cyrille Debard; Martine Laville; Hubert Vidal; Albert Tran; Philippe Gual; Yannick Le Marchand-Brustel; Mireille Cormont; Jean-François Tanti
Journal:  Diabetes       Date:  2009-10-06       Impact factor: 9.461
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