AIM: To gain insights into inter-strain differences in radiosensitivity. METHODS: Mice of inbred strains, A/J, C57BL/6J, and C3H/HeMs, were irradiated at graded doses ranging from 20 to 60 Gy. Skin reaction and leg contraction were observed for a period of 230 days and between 175 and 350 days, respectively. Gene expressions in leg skin tissue were quantified by quantitative RT-PCR assay at 1, 12 and 72 h after 30 Gy irradiation. Mice were locally irradiated by using a Cs-137 source. RESULTS: The three strains showed various degrees of susceptibility to irradiation has evaluated by skin scores. Large inter-strain differences were also detected in the lengths of contraction. Expressions of several genes such as Per3 and Rad51ap1 displayed inter-strain differences. CONCLUSIONS: The continuum model of tissue injury revealed that genetic factor, which varies among strains, is one of the causes of variances in severity of damage after irradiation.
AIM: To gain insights into inter-strain differences in radiosensitivity. METHODS:Mice of inbred strains, A/J, C57BL/6J, and C3H/HeMs, were irradiated at graded doses ranging from 20 to 60 Gy. Skin reaction and leg contraction were observed for a period of 230 days and between 175 and 350 days, respectively. Gene expressions in leg skin tissue were quantified by quantitative RT-PCR assay at 1, 12 and 72 h after 30 Gy irradiation. Mice were locally irradiated by using a Cs-137 source. RESULTS: The three strains showed various degrees of susceptibility to irradiation has evaluated by skin scores. Large inter-strain differences were also detected in the lengths of contraction. Expressions of several genes such as Per3 and Rad51ap1 displayed inter-strain differences. CONCLUSIONS: The continuum model of tissue injury revealed that genetic factor, which varies among strains, is one of the causes of variances in severity of damage after irradiation.
Authors: K E Applegate; W Rühm; A Wojcik; M Bourguignon; A Brenner; K Hamasaki; T Imai; M Imaizumi; T Imaoka; S Kakinuma; T Kamada; N Nishimura; N Okonogi; K Ozasa; C E Rübe; A Sadakane; R Sakata; Y Shimada; K Yoshida; S Bouffler Journal: Radiat Environ Biophys Date: 2020-03-07 Impact factor: 1.925
Authors: Keith A Cengel; Amit Maity; Theresa M Busch; Anastasia Velalopoulou; Ilias V Karagounis; Gwendolyn M Cramer; Michele M Kim; Giorgos Skoufos; Denisa Goia; Sarah Hagan; Ioannis I Verginadis; Khayrullo Shoniyozov; June Chiango; Michelle Cerullo; Kelley Varner; Lutian Yao; Ling Qin; Artemis G Hatzigeorgiou; Andy J Minn; Mary Putt; Matthew Lanza; Charles-Antoine Assenmacher; Enrico Radaelli; Jennifer Huck; Eric Diffenderfer; Lei Dong; James Metz; Constantinos Koumenis Journal: Cancer Res Date: 2021-07-28 Impact factor: 13.312
Authors: Raimon Duran-Struuck; Adam Hartigan; Shawn G Clouthier; Melissa C Dyson; Kathi Lowler; Erin Gatza; Isao Tawara; Tomomi Toubai; Elisabeth Weisiger; Kelly Hugunin; Pavan Reddy; John E Wilkinson Journal: J Transl Med Date: 2008-02-28 Impact factor: 5.531