| Literature DB >> 16164022 |
Babs O Fabriek1, Christine D Dijkstra, Timo K van den Berg.
Abstract
Mature tissue macrophages form a first line of defense to recognize and eliminate potential pathogens; these specialized cells are capable of phagocytosis, degradation of self and foreign materials, establishment of cell-cell interactions, and the production of inflammatory mediators. Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily members. CD163 is a member of the SRCR family class B and is expressed on most subpopulations of mature tissue macrophages. The best characterized function of CD163, which is essentially a homeostatic one, is related to the binding of Hemoglobin:Haptoglobin complexes. Furthermore, it has been suggested that CD163 positive macrophages or the soluble form of CD163 plays a role in the resolution of inflammation, as they are found in high numbers in inflamed tissue.Entities:
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Year: 2005 PMID： 16164022 DOI： 10.1016/j.imbio.2005.05.010
Source DB: PubMed Journal: Immunobiology ISSN： 0171-2985 Impact factor: 3.144