OBJECTIVES/ METHODS: Ten patients with neuropathologically verified frontotemporal dementia (FTD) were analysed for neuropathological features in relation to first presenting and dominating symptoms, age at onset and duration of dementia, as well as to EEG/quantitative EEG. RESULTS: Cases with a late onset (> 65 years) initially presented language disturbances, while the early onset group (< 65 years) showed predominantly behavioural symptoms and mood alterations as early features. The late onset group presented combined cortical-subcortical degeneration including white matter pathology, while early onset cases showed pathology predominantly in the cortex. EEG was normal in the late onset group, while it was mildly and variably abnormal in those with early onset. CONCLUSIONS: Within this small sample of clinical and neuropathological FTD, cases with late vs early onset differed with respect to initial symptoms, EEG findings and regional distribution of brain pathology. Copyright (c) 2005 John Wiley & Sons, Ltd.
OBJECTIVES/ METHODS: Ten patients with neuropathologically verified frontotemporal dementia (FTD) were analysed for neuropathological features in relation to first presenting and dominating symptoms, age at onset and duration of dementia, as well as to EEG/quantitative EEG. RESULTS: Cases with a late onset (> 65 years) initially presented language disturbances, while the early onset group (< 65 years) showed predominantly behavioural symptoms and mood alterations as early features. The late onset group presented combined cortical-subcortical degeneration including white matter pathology, while early onset cases showed pathology predominantly in the cortex. EEG was normal in the late onset group, while it was mildly and variably abnormal in those with early onset. CONCLUSIONS: Within this small sample of clinical and neuropathological FTD, cases with late vs early onset differed with respect to initial symptoms, EEG findings and regional distribution of brain pathology. Copyright (c) 2005 John Wiley & Sons, Ltd.
Authors: Jay L P Fieldhouse; Flora T Gossink; Thomas C Feenstra; Sterre C M de Boer; Afina W Lemstra; Niels D Prins; Femke Bouwman; Ted Koene; Hanneke F M Rhodius-Meester; Freek Gillissen; Charlotte E Teunissen; Wiesje M van der Flier; Philip Scheltens; Annemieke Dols; Everard G B Vijverberg; Yolande A L Pijnenburg Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472
Authors: Christian Sandøe Musaeus; Jette Stokholm Pedersen; Troels Wesenberg Kjær; Peter Johannsen; Gunhild Waldemar; Maria Joy Normann Haverberg; Theis Bacher; Jørgen Erik Nielsen; Peter Roos Journal: Front Aging Neurosci Date: 2021-09-13 Impact factor: 5.750