Literature DB >> 16162459

A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study.

K-S Kang1, S W Kim, Y H Oh, J W Yu, K-Y Kim, H K Park, C-H Song, H Han.   

Abstract

HLA-matched UC blood-derived multipotent stem cells were directly transplanted into the injured spinal cord site of a 37-year-old female patient suffering from spinal cord injury (SPI). In this case, human cord blood (UCB)-derived multipotent stem cells improved sensory perception and movement in the SPI patient's hips and thighs within 41 days of cell transplantation. CT and MRI results also showed regeneration of the spinal cord at the injured site and some of the cauda equina below it. Therefore, it is suggested that UCB multipotent stem cell transplantation could be a good treatment method for SPI patients.

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Year:  2005        PMID: 16162459     DOI: 10.1080/14653240500238160

Source DB:  PubMed          Journal:  Cytotherapy        ISSN: 1465-3249            Impact factor:   5.414


  36 in total

Review 1.  Transplantation of umbilical cord blood stem cells for treating spinal cord injury.

Authors:  Dong-Hyuk Park; Jeong-Hyun Lee; Cesario V Borlongan; Paul R Sanberg; Yong-Gu Chung; Tai-Hyoung Cho
Journal:  Stem Cell Rev Rep       Date:  2011-03       Impact factor: 5.739

2.  The application of umbilical cord blood cells in the treatment of diabetes mellitus.

Authors:  Tomas Koblas; S Mitchell Harman; Frantisek Saudek
Journal:  Rev Diabet Stud       Date:  2006-02-10

3.  Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era.

Authors:  Hongyun Huang; Lin Chen; Paul Sanberg
Journal:  Cell Med       Date:  2010-01-01

4.  Mesenchymal stromal cells from human perinatal tissues: From biology to cell therapy.

Authors:  Karen Bieback; Irena Brinkmann
Journal:  World J Stem Cells       Date:  2010-08-26       Impact factor: 5.326

5.  Immunophenotypic comparison of heterogenous non-sorted versus sorted mononuclear cells from human umbilical cord blood: a novel cell enrichment approach.

Authors:  S Indumathi; R Harikrishnan; J S Rajkumar; M Dhanasekaran
Journal:  Cytotechnology       Date:  2013-12-20       Impact factor: 2.058

6.  Intracerebroventricular Transplantation of Cord Blood-Derived Neural Progenitors in a Child With Severe Global Brain Ischemic Injury.

Authors:  Sergiusz Jozwiak; Aleksandra Habich; Katarzyna Kotulska; Anna Sarnowska; Tomasz Kropiwnicki; Miroslaw Janowski; Elzbieta Jurkiewicz; Barbara Lukomska; Tomasz Kmiec; Jerzy Walecki; Marcin Roszkowski; Mieczyslaw Litwin; Tomasz Oldak; Dariusz Boruczkowski; Krystyna Domanska-Janik
Journal:  Cell Med       Date:  2010-11-02

Review 7.  MicroRNA-based therapeutics in central nervous system injuries.

Authors:  Ping Sun; Da Zhi Liu; Glen C Jickling; Frank R Sharp; Ke-Jie Yin
Journal:  J Cereb Blood Flow Metab       Date:  2018-04-30       Impact factor: 6.200

Review 8.  Umbilical cord blood research: current and future perspectives.

Authors:  Jennifer D Newcomb; Paul R Sanberg; Stephen K Klasko; Alison E Willing
Journal:  Cell Transplant       Date:  2007       Impact factor: 4.064

Review 9.  Cord blood stem cells: a review of potential neurological applications.

Authors:  David T Harris
Journal:  Stem Cell Rev       Date:  2008-08-05       Impact factor: 5.739

10.  Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs.

Authors:  Ji Hey Lim; Ye Eun Byeon; Hak Hyun Ryu; Yun Hyeok Jeong; Young Won Lee; Wan Hee Kim; Kyung Sun Kang; Oh Kyeong Kweon
Journal:  J Vet Sci       Date:  2007-09       Impact factor: 1.672

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