BACKGROUND/AIMS: There are wide interindividual differences in the risk of developing alcoholic cirrhosis. Transforming growth factor beta(1) (TGF-beta(1)) is the main cytokine involved in liver fibrogenesis. The TGF-beta(1) gene is polymorphic at several sites and these polymorphisms are probably related to differences in the rate of TGF-beta(1) synthesis. Our aim has been to analyse the influence of the TGF-beta(1) gene polymorphisms in the predisposition to advanced alcoholic liver disease (ALD) in ethanol abusers. METHODS: TGF-beta(1) single nucleotide polymorphisms at positions -509 (C or T), +869 (C or T, codon 10), and +915 (C or G, codon 25) were examined in 165 alcoholics with advanced ALD and in 185 healthy controls. RESULTS: Among the 94 male patients with oesophageal varices, those carrying the GG genotype at position +915 were diagnosed at an older age than the remaining patients (age 52.1 years, standard deviation (SD) 9.9 vs. 45 SD 13.4, P=0.012). No other statistically significant differences were found in the distribution of the three TGF-beta(1) polymorphisms analysed individually or as combined haplotypes. CONCLUSIONS: The polymorphisms at the TGF-beta(1) gene analysed in this study are probably not related to the risk of advanced ALD.
BACKGROUND/AIMS: There are wide interindividual differences in the risk of developing alcoholic cirrhosis. Transforming growth factor beta(1) (TGF-beta(1)) is the main cytokine involved in liver fibrogenesis. The TGF-beta(1) gene is polymorphic at several sites and these polymorphisms are probably related to differences in the rate of TGF-beta(1) synthesis. Our aim has been to analyse the influence of the TGF-beta(1) gene polymorphisms in the predisposition to advanced alcoholic liver disease (ALD) in ethanol abusers. METHODS:TGF-beta(1) single nucleotide polymorphisms at positions -509 (C or T), +869 (C or T, codon 10), and +915 (C or G, codon 25) were examined in 165 alcoholics with advanced ALD and in 185 healthy controls. RESULTS: Among the 94 male patients with oesophageal varices, those carrying the GG genotype at position +915 were diagnosed at an older age than the remaining patients (age 52.1 years, standard deviation (SD) 9.9 vs. 45 SD 13.4, P=0.012). No other statistically significant differences were found in the distribution of the three TGF-beta(1) polymorphisms analysed individually or as combined haplotypes. CONCLUSIONS: The polymorphisms at the TGF-beta(1) gene analysed in this study are probably not related to the risk of advanced ALD.
Authors: Katja Breitkopf; Laura E Nagy; Juliane I Beier; Sebastian Mueller; Honglei Weng; Steven Dooley Journal: Alcohol Clin Exp Res Date: 2009-07-23 Impact factor: 3.455
Authors: Jong Joon Lee; Soo Kyung Park; Oh Sang Kwon; In Sik Won; Dong Kyu Kim; Young Kul Jung; Yang Suh Ku; Yun Soo Kim; Duck Joo Choi; Ju Hyun Kim Journal: Korean J Hepatol Date: 2011-03
Authors: Carmen Martínez; José A Molina; Hortensia Alonso-Navarro; Félix J Jiménez-Jiménez; José A G Agúndez; Elena García-Martín Journal: BMC Neurol Date: 2010-08-19 Impact factor: 2.474