PURPOSE: To investigate the role of inflammation in acute retinal artery occlusion (RAO). METHODS: Levels of interleukin (IL)-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) were measured in serum (n = 14) and aqueous humor (AqH) (n = 8) samples from patients with RAO. Findings were compared with 24 age- and disease-matched patients, 10 healthy subjects (serum), and 16 patients undergoing cataract surgery (AqH). RESULTS: Patients who arrived early (within 4-6 hours of occlusion) had higher serum IL-8 and IL-6 levels than controls; the IL-6 level in the AqH was lower than that of controls, while the IL-8 level was higher. In seven patients for whom both serum and AqH samples were available, serum IL-6 levels were higher than their corresponding AqH levels in most patients arriving within 10 hours of occlusion, and AqH IL-8 levels were higher than the corresponding serum levels in all but one. TNF-alpha levels were consistently higher in the serum than in the AqH at all time points. CONCLUSIONS: Serum IL-8 and IL-6 and AqH IL-8 are elevated immediately following acute RAO. The early local suppression of IL-6 may be related to ocular immune mechanisms.
PURPOSE: To investigate the role of inflammation in acute retinal artery occlusion (RAO). METHODS: Levels of interleukin (IL)-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) were measured in serum (n = 14) and aqueous humor (AqH) (n = 8) samples from patients with RAO. Findings were compared with 24 age- and disease-matched patients, 10 healthy subjects (serum), and 16 patients undergoing cataract surgery (AqH). RESULTS:Patients who arrived early (within 4-6 hours of occlusion) had higher serum IL-8 and IL-6 levels than controls; the IL-6 level in the AqH was lower than that of controls, while the IL-8 level was higher. In seven patients for whom both serum and AqH samples were available, serum IL-6 levels were higher than their corresponding AqH levels in most patients arriving within 10 hours of occlusion, and AqH IL-8 levels were higher than the corresponding serum levels in all but one. TNF-alpha levels were consistently higher in the serum than in the AqH at all time points. CONCLUSIONS: Serum IL-8 and IL-6 and AqH IL-8 are elevated immediately following acute RAO. The early local suppression of IL-6 may be related to ocular immune mechanisms.
Authors: Ping Chen; Alastair Denniston; Susan Hannes; William Tucker; Lai Wei; Baoying Liu; Tiaojiang Xiao; Sima Hirani; Zhiyu Li; Shayma Jawad; Han Si; Richard W J Lee; H Nida Sen; Robert B Nussenblatt Journal: Clin Immunol Date: 2015-03-14 Impact factor: 3.969
Authors: Michal Kramer; S Dadon; M Hasanreisoglu; Y Monselise; B R Avraham; A Feldman; I Eldar; D Weinberger; N Goldenberg-Cohen Journal: Mol Vis Date: 2009-05-01 Impact factor: 2.367
Authors: Matthew R Richardson; Marianne O Price; Francis W Price; Jennifer C Pardo; Juan C Grandin; Jinsam You; Mu Wang; Mervin C Yoder Journal: Mol Vis Date: 2009-12-11 Impact factor: 2.367