Christopher D Fahey1, Mark J Alberts, Richard A Bernstein. 1. Ken and Ruth Davee Department of Neurology and Clinical Neurological Sciences, Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA.
Abstract
INTRODUCTION: Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation. METHODS: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose oforal clopidogrel. RESULTS: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction. CONCLUSION: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.
RCT Entities:
INTRODUCTION:Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation. METHODS: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel. RESULTS: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction. CONCLUSION: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.