BACKGROUND: Cytokines reflect the activity of the immune system. We analyzed the local expression of characteristic cytokines indicating the level of activity of unspecific inflammatory cells, Th1-cells and Th2-cells in colon cancer. MATERIALS AND METHODS: In 25 tumor/ mucosa pairs, IL-1alpha, IL-2, IL-4, IL-5, IL-15, TNF-alpha and IFN-gamma were measured by real-time PCR. RESULTS: There was a significant increase in IL-1alpha, IL-4, IL-5 and TNF-alpha and a significant decrease in IL-2 in tumor tissue compared to normal mucosa. DISCUSSION: The cytokine profile in colon cancer indicates a strong unspecific inflammatory reaction in the tumor tissue represented by high levels of IL-1 and TNF-alpha. The comparatively low level of IL-2 suggests suppression of a specific immunological reaction, namely Th1-cells. It can be hypothesized that this is a result and/or cause of local immune escape mechanisms. Furthermore, there is an activation of TH2 cells in the carcinomas.
BACKGROUND: Cytokines reflect the activity of the immune system. We analyzed the local expression of characteristic cytokines indicating the level of activity of unspecific inflammatory cells, Th1-cells and Th2-cells in colon cancer. MATERIALS AND METHODS: In 25 tumor/ mucosa pairs, IL-1alpha, IL-2, IL-4, IL-5, IL-15, TNF-alpha and IFN-gamma were measured by real-time PCR. RESULTS: There was a significant increase in IL-1alpha, IL-4, IL-5 and TNF-alpha and a significant decrease in IL-2 in tumor tissue compared to normal mucosa. DISCUSSION: The cytokine profile in colon cancer indicates a strong unspecific inflammatory reaction in the tumor tissue represented by high levels of IL-1 and TNF-alpha. The comparatively low level of IL-2 suggests suppression of a specific immunological reaction, namely Th1-cells. It can be hypothesized that this is a result and/or cause of local immune escape mechanisms. Furthermore, there is an activation of TH2 cells in the carcinomas.
Authors: Paulina Czajka-Francuz; Tomasz Francuz; Sylwia Cisoń-Jurek; Aleksander Czajka; Marcin Fajkis; Bożena Szymczak; Maciej Kozaczka; Krzysztof Piotr Malinowski; Wojciech Zasada; Jerzy Wojnar; Jerzy Chudek Journal: Rep Pract Oncol Radiother Date: 2020-08-21
Authors: Nathaniel S Rial; Gwendal Lazennec; Anil R Prasad; Robert S Krouse; Peter Lance; Eugene W Gerner Journal: Int J Cancer Date: 2009-05-15 Impact factor: 7.396
Authors: Fausto Catena; Luca Ansaloni; Andrea Avanzolini; Salomone Di Saverio; Luigi D'Alessandro; Mario Maldini Casadei; Antonio Pinna Journal: Int J Colorectal Dis Date: 2009-03-13 Impact factor: 2.571
Authors: Imke Atreya; Carl C Schimanski; Christoph Becker; Stefan Wirtz; Heike Dornhoff; Elke Schnürer; Martin R Berger; Peter R Galle; Wolfgang Herr; Markus F Neurath Journal: Gut Date: 2007-06-12 Impact factor: 23.059