BACKGROUND: Locoregional treatments like photodynamic therapy (PDT), radiofrequency ablation (RFA) or hepatic artery infusion (HAI) of chemotherapeutics may be applied for unresectable colorectal liver metastases. We evaluated the effect of these treatments on the immune response in a rat colon tumour liver metastases model. METHOD: Wag/Rij rats were inoculated at day 0 with CC531 tumour cells at two sites in the liver. At day 15, one of two tumours was treated with RFA or PDT, or the liver was treated by HAI. Twelve days later (day 27), rats were rechallenged locally with CC531 cells in the liver or systemically with CC531 cells in the femoral vein. At day 42, tumour growth in liver and lungs was determined. RESULTS: RFA, PDT and HAI were very effective in liver tumour eradication, but following RFA or PDT there was no inhibitory effect on untreated nearby liver tumours. Outgrowth after local rechallenge was, however, significantly inhibited in RFA-, PDT- and HAI-treated rats, whereas all control rats showed outgrowth of a third liver tumour. After systemic rechallenge, control rats developed lung metastases whereas treated rats did not, but this difference was not statistically significant. CONCLUSION: These results show that following PDT, RFA and HAI resistance to local and possibly systemic tumour rechallenge is increased. This may be partly due to the induction or enhancement of a cellular immune response.
BACKGROUND: Locoregional treatments like photodynamic therapy (PDT), radiofrequency ablation (RFA) or hepatic artery infusion (HAI) of chemotherapeutics may be applied for unresectable colorectal liver metastases. We evaluated the effect of these treatments on the immune response in a ratcolon tumour liver metastases model. METHOD: Wag/Rij rats were inoculated at day 0 with CC531 tumour cells at two sites in the liver. At day 15, one of two tumours was treated with RFA or PDT, or the liver was treated by HAI. Twelve days later (day 27), rats were rechallenged locally with CC531 cells in the liver or systemically with CC531 cells in the femoral vein. At day 42, tumour growth in liver and lungs was determined. RESULTS: RFA, PDT and HAI were very effective in liver tumour eradication, but following RFA or PDT there was no inhibitory effect on untreated nearby liver tumours. Outgrowth after local rechallenge was, however, significantly inhibited in RFA-, PDT- and HAI-treated rats, whereas all control rats showed outgrowth of a third liver tumour. After systemic rechallenge, control rats developed lung metastases whereas treated rats did not, but this difference was not statistically significant. CONCLUSION: These results show that following PDT, RFA and HAI resistance to local and possibly systemic tumour rechallenge is increased. This may be partly due to the induction or enhancement of a cellular immune response.
Authors: N Kemeny; K Seiter; D Niedzwiecki; D Chapman; E Sigurdson; A Cohen; J Botet; P Oderman; P Murray Journal: Cancer Date: 1992-01-15 Impact factor: 6.860
Authors: Frederieke H van Duijnhoven; Remco I J M Aalbers; Joost Rothbarth; Onno T Terpstra; Peter J K Kuppen Journal: Clin Exp Metastasis Date: 2004 Impact factor: 5.150
Authors: Ergül Eyol; Annemarie Boleij; Rachel R Taylor; Andrew L Lewis; Martin R Berger Journal: Clin Exp Metastasis Date: 2008-02-08 Impact factor: 5.150
Authors: Marco A Alcala; Shu Ying Kwan; Chad M Shade; Megan Lang; Hyounsoo Uh; Manyan Wang; Stephen G Weber; David L Bartlett; Stéphane Petoud; Yong J Lee Journal: Nanomedicine Date: 2010-10-12 Impact factor: 5.307
Authors: Pieter de Heer; Maro H Sandel; Gunther Guertens; Gert de Boeck; Margaretha M Koudijs; J Fred Nagelkerke; Jan M C Junggeburt; Ernst A de Bruijn; Cornelis J H van de Velde; Peter J K Kuppen Journal: Cancer Chemother Pharmacol Date: 2008-02-05 Impact factor: 3.333