| Literature DB >> 16158063 |
Eva Gropp1, Marya Shanabrough, Erzsebet Borok, Allison W Xu, Ruth Janoschek, Thorsten Buch, Leona Plum, Nina Balthasar, Brigitte Hampel, Ari Waisman, Gregory S Barsh, Tamas L Horvath, Jens C Brüning.
Abstract
Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.Entities:
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Year: 2005 PMID： 16158063 DOI： 10.1038/nn1548
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884