OBJECTIVES: Anemia is observed in various malignancies including lung cancer and is recently considered to be a poor prognostic indicator. We investigated whether there is a correlation between anemia, other clinicopathologic factors, and survival. METHODS: We retrospectively examined the clinical records of 611 patients with lung cancer. RESULTS: Of those, 298 (48.8%) patients had anemia at the time of their first visit to our hospital. There was a significant correlation between anemia and age (p=0.0006) or ECOG performance status (p=0.0002), however, there was no correlation of anemia with gender, histological type, clinical stage, or serum level of lactate dehydrogenase. Survival was significantly shorter in 298 patients with anemia (median survival time (MST): 7.5 months) compared with 313 patients without anemia (MST: 11.8 months, p<0.0001). Multivariate analysis of prognostic factors using the Cox proportional hazards model revealed that anemia appeared to be an independent prognostic indicator. CONCLUSION: Anemia observed at the first presentation is an independent poor prognostic indicator in patients with lung cancer.
OBJECTIVES:Anemia is observed in various malignancies including lung cancer and is recently considered to be a poor prognostic indicator. We investigated whether there is a correlation between anemia, other clinicopathologic factors, and survival. METHODS: We retrospectively examined the clinical records of 611 patients with lung cancer. RESULTS: Of those, 298 (48.8%) patients had anemia at the time of their first visit to our hospital. There was a significant correlation between anemia and age (p=0.0006) or ECOG performance status (p=0.0002), however, there was no correlation of anemia with gender, histological type, clinical stage, or serum level of lactate dehydrogenase. Survival was significantly shorter in 298 patients with anemia (median survival time (MST): 7.5 months) compared with 313 patients without anemia (MST: 11.8 months, p<0.0001). Multivariate analysis of prognostic factors using the Cox proportional hazards model revealed that anemia appeared to be an independent prognostic indicator. CONCLUSION:Anemia observed at the first presentation is an independent poor prognostic indicator in patients with lung cancer.
Authors: Cynthia Owusu; Harvey Jay Cohen; Tao Feng; William Tew; Supriya G Mohile; Heidi D Klepin; Cary P Gross; Ajeet Gajra; Stuart M Lichtman; Arti Hurria Journal: J Natl Compr Canc Netw Date: 2015-10 Impact factor: 11.908
Authors: Mark Vincent; George Dranitsaris; Sunil Verma; Cathy Lau; Pere Gascon; Simon Van Belle; Heinz Ludwig Journal: Support Care Cancer Date: 2006-11-21 Impact factor: 3.603
Authors: Joanna Szkandera; Armin Gerger; Bernadette Liegl-Atzwanger; Michael Stotz; Hellmut Samonigg; Ferdinand Ploner; Tatjana Stojakovic; Andreas Leithner; Martin Pichler Journal: PLoS One Date: 2014-09-10 Impact factor: 3.240