| Literature DB >> 16157917 |
A Crespel1, P Genton, M Berramdane, P Coubes, C Monicard, M Baldy-Moulinier, P Gelisse.
Abstract
Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.Entities:
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Year: 2005 PMID： 16157917 DOI： 10.1212/01.wnl.0000174517.21383.36
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910