OBJECTIVE: To determine the clinical utility of the Frontal Assessment Battery (FAB), a short test of frontal lobe functions, in differentiating frontotemporal lobar degeneration (FTLD) from Alzheimer disease (AD). METHODS: FAB total scores and subscores for 23 subjects with FTLD and 31 subjects with AD were compared for sensitivity, specificity, and positive predictive value. Concurrent validity of the FAB with the Mini-Mental State Examination (MMSE) and other scales was also assessed. RESULTS: The FAB did not have positive predictive value for FTLD. Total FAB scores did not differ between the FTLD and AD groups. However, three subtests of the FAB (mental flexibility, motor programming, and environmental autonomy) demonstrated significant differences between the two groups. Total FAB scores correlated with scores on the MMSE, a more general test of cognition. CONCLUSION: The Frontal Assessment Battery did not discriminate subjects with frontotemporal lobar degeneration from those with Alzheimer disease, though certain subtests may be helpful in differential diagnosis.
OBJECTIVE: To determine the clinical utility of the Frontal Assessment Battery (FAB), a short test of frontal lobe functions, in differentiating frontotemporal lobar degeneration (FTLD) from Alzheimer disease (AD). METHODS: FAB total scores and subscores for 23 subjects with FTLD and 31 subjects with AD were compared for sensitivity, specificity, and positive predictive value. Concurrent validity of the FAB with the Mini-Mental State Examination (MMSE) and other scales was also assessed. RESULTS: The FAB did not have positive predictive value for FTLD. Total FAB scores did not differ between the FTLD and AD groups. However, three subtests of the FAB (mental flexibility, motor programming, and environmental autonomy) demonstrated significant differences between the two groups. Total FAB scores correlated with scores on the MMSE, a more general test of cognition. CONCLUSION: The Frontal Assessment Battery did not discriminate subjects with frontotemporal lobar degeneration from those with Alzheimer disease, though certain subtests may be helpful in differential diagnosis.
Authors: D Bruno; T Torralva; V Marenco; J Torres Ardilla; S Baez; E Gleichgerrcht; V Sinay; M Roca Journal: Neurol Sci Date: 2015-06-26 Impact factor: 3.307
Authors: Anne Hafkemeijer; Christiane Möller; Elise G P Dopper; Lize C Jiskoot; Tijn M Schouten; John C van Swieten; Wiesje M van der Flier; Hugo Vrenken; Yolande A L Pijnenburg; Frederik Barkhof; Philip Scheltens; Jeroen van der Grond; Serge A R B Rombouts Journal: Front Hum Neurosci Date: 2015-09-08 Impact factor: 3.169
Authors: Jee Wook Kim; Dong Young Lee; Eun Hyun Seo; Bo Kyung Sohn; Shin Young Park; Il Han Choo; Jong Chul Youn; Jin Hyeong Jhoo; Ki Woong Kim; Jong Inn Woo Journal: J Korean Med Sci Date: 2013-09-25 Impact factor: 2.153