| Literature DB >> 16157343 |
Noriko Nagi-Miura1, Toshie Harada, Hiroyasu Shinohara, Kiyoshi Kurihara, Yoshiyuki Adachi, Akiko Ishida-Okawara, Toshiaki Oharaseki, Kei Takahashi, Shiro Naoe, Kazuo Suzuki, Naohito Ohno.
Abstract
CAWS is a microbial pathogen-associated molecular patterns (PAMPs) produced by Candida albicans. CAWS is a mannoprotein-beta-glucan complex and secreted into the culture supernatant. CAWS has various biological effects, causing acute shock and disrupting vascular permeability. Intraperitoneal administration of CAWS induces coronary arteritis in various strains of inbred mice. The CAWS-induced coronary arteritis is strain-dependent and most severe in DBA/2 mice with a significant number of these animals expiring with cardiomegaly during the observation period. In vivo and in vitro, splenocytes of DBA/2 mice produced various cytokines, such as IL-6, TNF-alpha, and IFN-gamma in response to CAWS. GM-CSF was also produced in response to CAWS. The production of cytokines was significantly enhanced in the presence of recombinant GM-CSF. In contrast, anti-GM-CSF significantly reduced the production of TNF-alpha and IFN-gamma. Augmented production of cytokines in response to CAWS would be a key to the severity of coronary arteritis.Entities:
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Year: 2005 PMID： 16157343 DOI： 10.1016/j.atherosclerosis.2005.08.014
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162