Literature DB >> 16157215

The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans.

Harald Moonen1, Leopold Engels, Jos Kleinjans, Theo de Kok.   

Abstract

Colorectal cancer (CRC) is believed to be related to the intake of processed meat and the formed heterocyclic aromatic amines (HCA) herein, which are metabolically activated by the enzymes cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2). The influence of genotypic and phenotypic variations for CYP1A2 and NAT2 on the risk for colorectal adenomas was investigated in 94 individuals at different risk of developing CRC. Significant associations were found between the CYP1A2-164A-->C polymorphism (CYP1A2*1F) and the risk of colorectal adenomas, suggesting that the studied polymorphism plays an important role in CRC risk in humans.

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Year:  2005        PMID： 16157215     DOI： 10.1016/j.canlet.2004.12.010

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

1.  Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk.

Authors:  Monika Eichholzer; Sabine Rohrmann; Aline Barbir; Silke Hermann; Birgit Teucher; Rudolf Kaaks; Jakob Linseisen
Journal:  Int J Mol Epidemiol Genet       Date:  2012-05-15

Review 2.  Quantitative Proteomics in Translational Absorption, Distribution, Metabolism, and Excretion and Precision Medicine.

Authors:  Deepak Ahire; Laken Kruger; Sheena Sharma; Vijaya Saradhi Mettu; Abdul Basit; Bhagwat Prasad
Journal:  Pharmacol Rev       Date:  2022-07       Impact factor: 18.923

3.  Polymorphisms in xenobiotic metabolizing genes, intakes of heterocyclic amines and red meat, and postmenopausal breast cancer.

Authors:  Hae-Jeung Lee; Kana Wu; David G Cox; David Hunter; Susan E Hankinson; Walter C Willett; Rashmi Sinha; Eunyoung Cho
Journal:  Nutr Cancer       Date:  2013-10-07       Impact factor: 2.900

4.  Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection.

Authors:  Ujjala Ghoshal; Shweta Tripathi; Sushil Kumar; Balraj Mittal; Dipti Chourasia; Niraj Kumari; Narendra Krishnani; Uday C Ghoshal
Journal:  Gastric Cancer       Date:  2013-05-19       Impact factor: 7.370

5.  Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae.

Authors:  Michael Fasullo; Autumn Smith; Patricia Egner; Cinzia Cera
Journal:  Mutat Res Genet Toxicol Environ Mutagen       Date:  2014-01-25       Impact factor: 2.873

6.  Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.

Authors:  Aesun Shin; Martha J Shrubsole; Jeffrey M Rice; Qiuyin Cai; Mark A Doll; Jirong Long; Walter E Smalley; Yu Shyr; Rashmi Sinha; Reid M Ness; David W Hein; Wei Zheng
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-02       Impact factor: 4.254

7.  Impaired Metabolic Pathways Related to Colorectal Cancer Progression and Therapeutic Implications.

Authors:  Chunyan Qiu; Yue Zhang; Longhua Chen
Journal:  Iran J Public Health       Date:  2020-01       Impact factor: 1.429

8.  Association of NAT2 polymorphisms with risk of colorectal adenomas: Evidence from 3,197 cases and 4,681 controls.

Authors:  Wenlei Zhuo; Liang Zhang; Zhiqun Qiu; Lei Cai; Bo Zhu; Zhengtang Chen
Journal:  Exp Ther Med       Date:  2012-09-04       Impact factor: 2.447

9.  Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.

Authors:  Lara Bethke; Emily Webb; Gabrielle Sellick; Matthew Rudd; Stephen Penegar; Laura Withey; Mobshra Qureshi; Richard Houlston
Journal:  BMC Cancer       Date:  2007-07-05       Impact factor: 4.430
  9 in total

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