OBJECTIVE: The purpose of this study was to determine if women with preeclampsia are more likely to have a sister who also had preeclampsia. STUDY DESIGN: This was a population-based case-control study using data from Washington (WA) state birth certificates linked to hospital discharge records. Cases were women with gestational hypertension (n = 1611) or preeclampsia (n = 1071); controls (n = 8041) had normotensive pregnancies. All women delivered their first child between 1987 to 2002 and had a sister with a previous delivery in WA. RESULTS: Women with preeclampsia were 2.3 times (95%CI 1.8-2.9) more likely to have a sister who had preeclampsia; those with gestational hypertension were 1.6 times (95%CI 1.3-2.0) more likely to have a sister with gestational hypertension. Similar results were obtained following stratification by age, race, smoking status, or body mass index. CONCLUSION: The greater likelihood of preeclampsia among sisters of women with a previous preeclamptic pregnancy is consistent with a pathophysiologic role for genetic and/or behavioral factors that cluster in families.
OBJECTIVE: The purpose of this study was to determine if women with preeclampsia are more likely to have a sister who also had preeclampsia. STUDY DESIGN: This was a population-based case-control study using data from Washington (WA) state birth certificates linked to hospital discharge records. Cases were women with gestational hypertension (n = 1611) or preeclampsia (n = 1071); controls (n = 8041) had normotensive pregnancies. All women delivered their first child between 1987 to 2002 and had a sister with a previous delivery in WA. RESULTS:Women with preeclampsia were 2.3 times (95%CI 1.8-2.9) more likely to have a sister who had preeclampsia; those with gestational hypertension were 1.6 times (95%CI 1.3-2.0) more likely to have a sister with gestational hypertension. Similar results were obtained following stratification by age, race, smoking status, or body mass index. CONCLUSION: The greater likelihood of preeclampsia among sisters of women with a previous preeclamptic pregnancy is consistent with a pathophysiologic role for genetic and/or behavioral factors that cluster in families.
Authors: Darcy R Barry; Kristina M Utzschneider; Jenny Tong; Kersten Gaba; Daniel F Leotta; John D Brunzell; Thomas R Easterling Journal: Am J Obstet Gynecol Date: 2015-05-21 Impact factor: 8.661
Authors: E Fitzpatrick; M P Johnson; T D Dyer; S Forrest; K Elliott; J Blangero; S P Brennecke; E K Moses Journal: Mol Hum Reprod Date: 2009-01-06 Impact factor: 4.025
Authors: Robyn A North; Lesley M E McCowan; Gustaaf A Dekker; Lucilla Poston; Eliza H Y Chan; Alistair W Stewart; Michael A Black; Rennae S Taylor; James J Walker; Philip N Baker; Louise C Kenny Journal: BMJ Date: 2011-04-07