Effects of hypophysectomy and testosterone treatment on the urinary excretion of zenarestat in rats.

1. The effects of hypophysectomy and androgen treatment on the urinary excretion of zenarestat were investigated in Sprague-Dawley rats. 2. Hypophysectomized male rats and normal female rats has similar urinary excretion of zenarestat which was much greater than that of normal male rats. 3. Treatment of male and female hypophysectomized rats with testosterone resulted in the urinary excretion of zenarestat characteristic of intact adult male rats. 4. Urinary secretion of zenarestat in rats is independent of pituitary hormone and is suppressed only by androgen.