OBJECTIVE: To test the hypothesis that untreated overt and subclinical thyroid disorders and autoimmune thyroiditis (AIT) are associated with mental and physical complaints in the general population. METHOD: A total of 3790 participants from the Study of Health in Pomerania (SHIP) with no known thyroid disorders were analyzed concerning their thyroid function (TSH, FT3, FT4), autoantibodies (TPO-Ab), their thyroid structure and size and their mental and physical complaints (Zerssen Complaint Scale). RESULTS: Overt hyperthyroidism (prevalence: 0.4%) was associated with a significantly lower total complaint-score than euthyroid subjects. Subjects with overt hypothyroidism (0.5%), subclinical hypothyroidism (0.7%), or subclinical hyperthyroidism (1.6%) were not different from controls in their total complaints. Females with AIT showed higher scores of tachycardia and anxiety independent from their thyroid function. CONCLUSION: In non-patient samples, hyperthyroidism is associated with positive effects on self-rated mental and physical health. AIT may be associated with negative effects on health also in euthyroid subjects.
OBJECTIVE: To test the hypothesis that untreated overt and subclinical thyroid disorders and autoimmune thyroiditis (AIT) are associated with mental and physical complaints in the general population. METHOD: A total of 3790 participants from the Study of Health in Pomerania (SHIP) with no known thyroid disorders were analyzed concerning their thyroid function (TSH, FT3, FT4), autoantibodies (TPO-Ab), their thyroid structure and size and their mental and physical complaints (Zerssen Complaint Scale). RESULTS: Overt hyperthyroidism (prevalence: 0.4%) was associated with a significantly lower total complaint-score than euthyroid subjects. Subjects with overt hypothyroidism (0.5%), subclinical hypothyroidism (0.7%), or subclinical hyperthyroidism (1.6%) were not different from controls in their total complaints. Females with AIT showed higher scores of tachycardia and anxiety independent from their thyroid function. CONCLUSION: In non-patient samples, hyperthyroidism is associated with positive effects on self-rated mental and physical health. AIT may be associated with negative effects on health also in euthyroid subjects.
Authors: Andreas Reif; T Trang Nguyen; Lena Weissflog; Christian P Jacob; Marcel Romanos; Tobias J Renner; Henriette N Buttenschon; Sarah Kittel-Schneider; Alexandra Gessner; Heike Weber; Maria Neuner; Silke Gross-Lesch; Karin Zamzow; Susanne Kreiker; Susanne Walitza; Jobst Meyer; Christine M Freitag; Rosa Bosch; Miquel Casas; Nuria Gómez; Marta Ribasès; Mónica Bayès; Jan K Buitelaar; Lambertus A L M Kiemeney; J J Sandra Kooij; Cees C Kan; Martine Hoogman; Stefan Johansson; Kaya K Jacobsen; Per M Knappskog; Ole B Fasmer; Phil Asherson; Andreas Warnke; Hans-Jörgen Grabe; Jessie Mahler; Alexander Teumer; Henry Völzke; Ole N Mors; Helmut Schäfer; Josep Antoni Ramos-Quiroga; Bru Cormand; Jan Haavik; Barbara Franke; Klaus-Peter Lesch Journal: Neuropsychopharmacology Date: 2011-07-13 Impact factor: 7.853
Authors: Eva-Maria Siegmann; Helge H O Müller; Caroline Luecke; Alexandra Philipsen; Johannes Kornhuber; Teja Wolfgang Grömer Journal: JAMA Psychiatry Date: 2018-06-01 Impact factor: 21.596
Authors: Till Ittermann; Henry Völzke; Sebastian E Baumeister; Katja Appel; Hans J Grabe Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2015-03-17 Impact factor: 4.328
Authors: Stefanie A Samietz; Stefan Kindler; Christian Schwahn; Ines Polzer; Wolfgang Hoffmann; Thomas Kocher; Hans Jörgen Grabe; Torsten Mundt; Reiner Biffar Journal: Clin Oral Investig Date: 2012-08-03 Impact factor: 3.573
Authors: Franziska Struch; Christian Schwahn; Henri Wallaschofski; Hans J Grabe; Henry Völzke; Markus M Lerch; Peter Meisel; Thomas Kocher Journal: J Gen Intern Med Date: 2008-01-15 Impact factor: 5.128