Literature DB >> 16156521

Ushikulides A and B, immunosuppressants produced by a strain of Streptomyces sp.

Kosaku Takahashi1, Teruhiko Yoshihara, Kazuhiko Kurosawa.   

Abstract

Novel immunosuppressants, ushikulides A and B, were isolated from the culture broth of Streptomyces sp. IUK-102. Ushikulides A and B both have the same molecular formula, determined as C40H68O10. The structures of both compounds were elucidated to be novel 22-membered macrolides. Both compounds showed immunosuppressive activity for murine splenocyte proliferation in vitro.

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Year:  2005        PMID: 16156521     DOI: 10.1038/ja.2005.55

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  5 in total

1.  Total synthesis and stereochemical assignment of (-)-ushikulide A.

Authors:  Barry M Trost; Brendan M O'Boyle; Daniel Hund
Journal:  J Am Chem Soc       Date:  2009-10-21       Impact factor: 15.419

2.  Exploiting orthogonally reactive functionality: synthesis and stereochemical assignment of (-)-ushikulide A.

Authors:  Barry M Trost; Brendan M O'Boyle
Journal:  J Am Chem Soc       Date:  2008-12-03       Impact factor: 15.419

3.  A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete of the genus Pseudosporangium.

Authors:  Shun Saito; Kota Atsumi; Tao Zhou; Keisuke Fukaya; Daisuke Urabe; Naoya Oku; Md Rokon Ul Karim; Hisayuki Komaki; Yasuhiro Igarashi
Journal:  Beilstein J Org Chem       Date:  2020-05-25       Impact factor: 2.883

4.  The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety.

Authors:  Oksana Bilyk; Markiyan Samborskyy; Peter F Leadlay
Journal:  PLoS One       Date:  2019-04-30       Impact factor: 3.240

5.  Metabolomics Tools Assisting Classic Screening Methods in Discovering New Antibiotics from Mangrove Actinomycetia in Leizhou Peninsula.

Authors:  Qin-Pei Lu; Yong-Mei Huang; Shao-Wei Liu; Gang Wu; Qin Yang; Li-Fang Liu; Hai-Tao Zhang; Yi Qi; Ting Wang; Zhong-Ke Jiang; Jun-Jie Li; Hao Cai; Xiu-Jun Liu; Hui Luo; Cheng-Hang Sun
Journal:  Mar Drugs       Date:  2021-12-01       Impact factor: 5.118

  5 in total

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