Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Organism complexity anti-correlates with proteomic beta-aggregation propensity.

Literature DB >> 16155201

Organism complexity anti-correlates with proteomic beta-aggregation propensity.

Gian Gaetano Tartaglia¹, Riccardo Pellarin, Andrea Cavalli, Amedeo Caflisch.

Abstract

We introduce a novel approach to estimate differences in the beta-aggregation potential of eukaryotic proteomes. The approach is based on a statistical analysis of the beta-aggregation propensity of polypeptide segments, which is calculated by an equation derived from first principles using the physicochemical properties of the natural amino acids. Our analysis reveals a significant decreasing trend of the overall beta-aggregation tendency with increasing organism complexity and longevity. A comparison with randomized proteomes shows that natural proteomes have a higher degree of polarization in both low and high beta-aggregation prone sequences. The former originates from the requirement of intrinsically disordered proteins, whereas the latter originates from the necessity of proteins with a stable folded structure.

Entities: Disease

Mesh：

Substances：
Proteins
Proteome

Year: 2005 PMID： 16155201 PMCID： PMC2253303 DOI： 10.1110/ps.051473805

Source DB: PubMed Journal: Protein Sci ISSN： 0961-8368 Impact factor: 6.725

32 in total

1. The protein non-folding problem: amino acid determinants of intrinsic order and disorder.

Authors: R M Williams; Z Obradovi; V Mathura; W Braun; E C Garner; J Young; S Takayama; C J Brown; A K Dunker
Journal: Pac Symp Biocomput Date: 2001

Review 2. Protein misfolding, evolution and disease.

Authors: C M Dobson
Journal: Trends Biochem Sci Date: 1999-09 Impact factor: 13.807

Review 3. Amyloid fibrillogenesis: themes and variations.

Authors: J C Rochet; P T Lansbury
Journal: Curr Opin Struct Biol Date: 2000-02 Impact factor: 6.809

4. The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates.

Authors: Gian Gaetano Tartaglia; Andrea Cavalli; Riccardo Pellarin; Amedeo Caflisch
Journal: Protein Sci Date: 2004-05-28 Impact factor: 6.725

5. A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins.

Authors: Rune Linding; Joost Schymkowitz; Frederic Rousseau; Francesca Diella; Luis Serrano
Journal: J Mol Biol Date: 2004-09-03 Impact factor: 5.469

Review 6. Construction of phylogenetic trees.

Authors: W M Fitch; E Margoliash
Journal: Science Date: 1967-01-20 Impact factor: 47.728

7. Energetics of complementary side-chain packing in a protein hydrophobic core.

Authors: J T Kellis; K Nyberg; A R Fersht
Journal: Biochemistry Date: 1989-05-30 Impact factor: 3.162

8. Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.

Authors: Martin Theis; Kausik Si; Eric R Kandel
Journal: Proc Natl Acad Sci U S A Date: 2003-07-18 Impact factor: 11.205

9. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

Authors: J J Ward; J S Sodhi; L J McGuffin; B F Buxton; D T Jones
Journal: J Mol Biol Date: 2004-03-26 Impact factor: 5.469

10. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

Authors: Kausik Si; Maurizio Giustetto; Amit Etkin; Ruby Hsu; Agnieszka M Janisiewicz; Maria Conchetta Miniaci; Joung-Hun Kim; Huixiang Zhu; Eric R Kandel
Journal: Cell Date: 2003-12-26 Impact factor: 41.582

16 in total

Organism complexity anti-correlates with proteomic beta-aggregation propensity.

1. The protein non-folding problem: amino acid determinants of intrinsic order and disorder.

Review 2. Protein misfolding, evolution and disease.

Review 3. Amyloid fibrillogenesis: themes and variations.

4. The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates.

5. A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins.

Review 6. Construction of phylogenetic trees.

7. Energetics of complementary side-chain packing in a protein hydrophobic core.

8. Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.

9. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

10. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

1. Natural selection against protein aggregation on self-interacting and essential proteins in yeast, fly, and worm.

2. A Shift in Aggregation Avoidance Strategy Marks a Long-Term Direction to Protein Evolution.

3. Increased levels of hyper-stable protein aggregates in plasma of older adults.

4. Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences.

5. Protein aggregation profile of the bacterial cytosol.

Review 6. Folding versus aggregation: polypeptide conformations on competing pathways.

7. Cellular strategies for regulating functional and nonfunctional protein aggregation.

8. Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.

9. Protein aggregation profile of the human kinome.

10. Aggregation is a Context-Dependent Constraint on Protein Evolution.