Literature DB >> 16154855

Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis.

Jin Zhou, Ran Meng, Xinhua Sui, Lu Meng, Jianping Jia, Baofeng Yang.   

Abstract

We studied the effects of varying and steady-state concentrations of arsenic trioxide (As2O3) on apoptosis and differentiation of several cell lines in vitro. We also studied the same effects of fluctuating vs constant concentrations of As2O3 in vivo in patients treated with daily 3-hour fast infusions or daily slow, continuous infusions. Intracellular concentrations of arsenic and apoptosis rate were higher whereas differentiation was reduced in cells exposed to constant concentrations of As2O3.

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Year:  2005        PMID： 16154855

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  7 in total

Review 1.  The evolution of arsenic in the treatment of acute promyelocytic leukemia and other myeloid neoplasms: Moving toward an effective oral, outpatient therapy.

Authors:  Lorenzo Falchi; Srdan Verstovsek; Farhad Ravandi-Kashani; Hagop M Kantarjian
Journal:  Cancer       Date:  2015-12-30       Impact factor: 6.860

2.  The comparison of plasma arsenic concentration and urinary arsenic excretion during treatment with Realgar-Indigo naturalis formula and arsenic trioxide in children with acute promyelocytic leukemia.

Authors:  Liu-Hua Liao; Yi-Qiao Chen; Dan-Ping Huang; Li-Na Wang; Zhong-Lu Ye; Li-Hua Yang; Hui-Rong Mai; Yu Li; Cong Liang; Jie-Si Luo; Li-Na Wang; Xue-Qun Luo; Yan-Lai Tang; Xiao-Li Zhang; Li-Bin Huang
Journal:  Cancer Chemother Pharmacol       Date:  2022-06-27       Impact factor: 3.288

3.  Oral Realgar-Indigo Naturalis Formula Treatment for Acute Promyelocytic Leukemia in Children: A Randomized, Control Clinical Trial.

Authors:  Senlin Luo; Jidong Tian; Xiao Sun; Feifeng Wu; Ying Liu; Wuqing Wan; Zhou She; Chuan Wen
Journal:  Evid Based Complement Alternat Med       Date:  2022-07-05       Impact factor: 2.650

4.  Preparation, characterization, in vivo and in vitro studies of arsenic trioxide Mg-Fe ferrite magnetic nanoparticles.

Authors:  Guo-fu Yang; Xiang-hui Li; Zhe Zhao; Wen-bo Wang
Journal:  Acta Pharmacol Sin       Date:  2009-12       Impact factor: 6.150

5.  Gene mutations in acute promyelocytic leukemia early death in patients treated with arsenic trioxide alone.

Authors:  Xiaotong Chen; Shengjin Fan; Yanqiu Zhao; Jin Zhou
Journal:  Clin Transl Oncol       Date:  2021-05-03       Impact factor: 3.405

Review 6.  Acute Promyelocytic Leukemia in Children: A Model of Precision Medicine and Chemotherapy-Free Therapy.

Authors:  Carmelo Gurnari; Maria Teresa Voso; Katia Girardi; Angela Mastronuzzi; Luisa Strocchio
Journal:  Int J Mol Sci       Date:  2021-01-11       Impact factor: 5.923

7.  Multicenter randomized trial of arsenic trioxide and Realgar-Indigo naturalis formula in pediatric patients with acute promyelocytic leukemia: Interim results of the SCCLG-APL clinical study.

Authors:  Ming-Hua Yang; Wu-Qing Wan; Jie-Si Luo; Min-Cui Zheng; Ke Huang; Li-Hua Yang; Hui-Rong Mai; Jian Li; Hui-Qin Chen; Xiao-Fei Sun; Ri-Yang Liu; Guo-Hua Chen; Xiaoqin Feng; Zhi-Yong Ke; Bin Li; Yan-Lai Tang; Li-Bin Huang; Xue-Qun Luo
Journal:  Am J Hematol       Date:  2018-10-20       Impact factor: 10.047
  7 in total

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