Literature DB >> 16154531

Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.

Kiichi Hirota1, Gregg L Semenza.   

Abstract

Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.

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Year:  2005        PMID： 16154531     DOI： 10.1016/j.bbrc.2005.08.193

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  85 in total

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10.  Baicalin promotes extracellular matrix synthesis in chondrocytes via the activation of hypoxia-inducible factor-1α.

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