| Literature DB >> 16154154 |
Mark L Kuijf1, Pieter A van Doorn, Anne P Tio-Gillen, Karin Geleijns, C Wim Ang, Herbert Hooijkaas, Wim C J Hop, Bart C Jacobs.
Abstract
The Inflammatory Neuropathy and Treatment (INCAT) group developed a standardized ELISA method for the detection of serum anti-GM1 antibodies. The diagnostic value of anti-GM1 antibodies determined by this method has not yet been established in large groups of patients. We assessed the reproducibility, sources of variation, optimal cut-off values and evaluated the diagnostic relevance of the INCAT-ELISA in various groups of patients and controls (N=1232). The coefficient of variance was 11.2% for IgM and 3.8% for IgG. High IgG titers were only found in Guillain-Barré syndrome (GBS) and other inflammatory polyneuropathies. High IgM titers were associated with GBS and multifocal motor neuropathy. Low IgM titers had no additional diagnostic value. The INCAT-ELISA is a reliable test with additional diagnostic value in specific clinical situations.Entities:
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Year: 2005 PMID： 16154154 DOI： 10.1016/j.jns.2005.07.009
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181