| Literature DB >> 16153845 |
James F Dropinski1, Taro Akiyama, Monica Einstein, Bahanu Habulihaz, Tom Doebber, Joel P Berger, Peter T Meinke, Guo Q Shi.
Abstract
A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARgamma modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.Entities:
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Year: 2005 PMID： 16153845 DOI： 10.1016/j.bmcl.2005.08.002
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823