| Literature DB >> 16153835 |
Mark J Dixon1, Ole A Andersen, Daan M F van Aalten, Ian M Eggleston.
Abstract
The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.Entities:
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Year: 2005 PMID： 16153835 DOI： 10.1016/j.bmcl.2005.07.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823