Literature DB >> 16153832

Pyrazolopyridinones as functionally selective GABAA ligands.

Wesley P Blackaby1, John R Atack, Frances Bromidge, Richard Lewis, Michael G N Russell, Alison Smith, Keith Wafford, Ruth M McKernan, Leslie J Street, José L Castro.   

Abstract

2,5-Dihydro-3H-pyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands, which can exhibit functional selectivity for the alpha3 subtype over the alpha1 subtype. SAR studies to optimize this functional selectivity are described.

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Year:  2005        PMID： 16153832     DOI： 10.1016/j.bmcl.2005.08.006

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.

Authors:  Felix M Rivas; James P Stables; Lauren Murphree; Rahul V Edwankar; Chitra R Edwankar; Shengming Huang; Hiteshkumar D Jain; Hao Zhou; Samarpan Majumder; Subramanian Sankar; Bryan L Roth; Joachim Ramerstorfer; Roman Furtmüller; Werner Sieghart; James M Cook
Journal:  J Med Chem       Date:  2009-04-09       Impact factor: 7.446

2.  Divergent Mechanisms of the Banert Cascade with Propargyl Azides.

Authors:  Juliana R Alexander; Mary H Packard; Alanna M Hildebrandt; Amy A Ott; Joseph J Topczewski
Journal:  J Org Chem       Date:  2020-01-24       Impact factor: 4.354

3.  Intercepting the Banert cascade with nucleophilic fluorine: direct access to α-fluorinated NH-1,2,3-triazoles.

Authors:  J R Alexander; P V Kevorkian; J J Topczewski
Journal:  Chem Commun (Camb)       Date:  2021-05-20       Impact factor: 6.222
  3 in total

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