Literature DB >> 16153240

Zwitterionic capsular polysaccharides: the new MHCII-dependent antigens.

Brian A Cobb1, Dennis L Kasper.   

Abstract

The immune system has evolved the ability for T cells to recognize nearly any biological polymer, including peptides, protein superantigens, and glycolipids through presentation by the major histocompatibility complex (MHC) proteins such as MHC class I (MHCI), MHC class II (MHCII), and CD1. A recent and unexpected addition to this list is the zwitterionic capsular polysaccharide (ZPS). These bacterial molecules utilize MHCII presentation to activate T cells via recognition by alphabeta T cell receptor (alphabetaTCR) proteins. In this review, we explore what is currently known about ZPS processing and presentation within antigen-presenting cells (APCs) and the immune response that follows.

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Year:  2005        PMID： 16153240     DOI： 10.1111/j.1462-5822.2005.00591.x

Source DB:  PubMed          Journal:  Cell Microbiol        ISSN： 1462-5814            Impact factor:   3.715


  30 in total

1.  Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.

Authors:  Colleen J Lewis; Brian A Cobb
Journal:  Eur J Immunol       Date:  2011-08-04       Impact factor: 5.532

2.  In vitro immunogenic and immunostimulatory effects of zwitterionized 23-valent pneumococcal polysaccharide vaccine compared with nonzwitterionized vaccine.

Authors:  Ahmed S Abdulamir; Rand R Hafidh; Fatimah Abubaker
Journal:  Curr Ther Res Clin Exp       Date:  2010-02

Review 3.  The Gut Microbiome and Multiple Sclerosis.

Authors:  Javier Ochoa-Repáraz; Trevor O Kirby; Lloyd H Kasper
Journal:  Cold Spring Harb Perspect Med       Date:  2018-06-01       Impact factor: 6.915

4.  Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling.

Authors:  Colleen J Lewis; Brian A Cobb
Journal:  J Immunol       Date:  2010-03-03       Impact factor: 5.422

5.  De-N-acetylated sialic acid is immunogenic and elicits antibodies that are protective against Neisseria meningitidis.

Authors:  Gregory R Moe; Becca A Flitter; Jessica Y Ing; Tamara S Bhandari; Hardeep Kaur
Journal:  Vaccimonitor       Date:  2009

6.  Immunomodulatory glycan lacto-N-fucopentaose III requires clathrin-mediated endocytosis to induce alternative activation of antigen-presenting cells.

Authors:  Leena Srivastava; Smanla Tundup; Beak-San Choi; Thomas Norberg; Donald Harn
Journal:  Infect Immun       Date:  2014-02-24       Impact factor: 3.441

7.  Different Immunological Pathways Underlie the Immune Response to Pneumococcal Polysaccharides.

Authors:  Leen Moens; Capucine Picard; Mohammad Shahrooei; Greet Wuyts; Adrian Liston; Alain Fischer; Xavier Bossuyt
Journal:  J Clin Immunol       Date:  2017-03-16       Impact factor: 8.317

8.  Evidence for dendritic cell-dependent CD4(+) T helper-1 type responses to commensal bacteria in normal human intestinal lamina propria.

Authors:  Rawleigh Howe; Stephanie Dillon; Lisa Rogers; Martin McCarter; Caleb Kelly; Ricardo Gonzalez; Nancy Madinger; Cara C Wilson
Journal:  Clin Immunol       Date:  2009-01-25       Impact factor: 3.969

9.  The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism.

Authors:  Christopher Weidenmaier; Rachel M McLoughlin; Jean C Lee
Journal:  PLoS One       Date:  2010-10-07       Impact factor: 3.240

10.  Functional identification of a galactosyltransferase critical to Bacteroides fragilis Capsular Polysaccharide A biosynthesis.

Authors:  Jerry M Troutman; Sunita Sharma; Katelyn M Erickson; Christina D Martinez
Journal:  Carbohydr Res       Date:  2014-06-14       Impact factor: 2.104
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