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Literature DB >> 16151742

Degradation of human secretory immunoglobulin A by Blastocystis.

Manoj K Puthia¹, Aparna Vaithilingam, Jia Lu, Kevin S W Tan.

Abstract

Microbial immunoglobulin A (IgA) proteases cleave human secretory IgA, promoting the mucosal adhesion of pathogens. To investigate if the enteric protozoan Blastocystis degrades human secretory IgA, cell lysate and conditioned medium from two species were exposed to immunoglobulin A. Secretory IgA was cleaved by both cell lysate and conditioned medium with mainly cysteine proteinase activity in B. hominis B isolate and aspartic proteinase activity in B. ratii WR1 isolate. These findings suggest that Blastocystis proteases may play a role in parasite survival in vivo.

Entities: Disease Species

Mesh：

Substances：

Year: 2005 PMID： 16151742 DOI： 10.1007/s00436-005-1461-0

Source DB: PubMed Journal: Parasitol Res ISSN： 0932-0113 Impact factor: 2.289

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