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Literature DB >> 16151519

Tissue plasminogen activator, neuroserpin, and seizures.

Annamaria Vezzani.

Abstract

Entities: Disease Gene

Year: 2005 PMID： 16151519 PMCID： PMC1198732 DOI： 10.1111/j.1535-7511.2005.00041.x

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.500

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11 in total

1. Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen. Role in the regulation of fibrinolysis and identification as histidine-rich glycoprotein.

Authors: H R Lijnen; M Hoylaerts; D Collen
Journal: J Biol Chem Date: 1980-11-10 Impact factor: 5.157

2. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

Authors: O Nicole; F Docagne; C Ali; I Margaill; P Carmeliet; E T MacKenzie; D Vivien; A Buisson
Journal: Nat Med Date: 2001-01 Impact factor: 53.440

3. Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy.

Authors: M Takao; M D Benson; J R Murrell; M Yazaki; P Piccardo; F W Unverzagt; R L Davis; P D Holohan; D A Lawrence; R Richardson; M R Farlow; B Ghetti
Journal: J Neuropathol Exp Neurol Date: 2000-12 Impact factor: 3.685

4. Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.

Authors: Robert Pawlak; Jerry P Melchor; Tomasz Matys; Anna E Skrzypiec; Sidney Strickland
Journal: Proc Natl Acad Sci U S A Date: 2005-01-03 Impact factor: 11.205

Review 5. New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system.

Authors: Manuel Yepes; Daniel A Lawrence
Journal: Exp Biol Med (Maywood) Date: 2004-12

10. Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.

Authors: Didier Belorgey; Lynda K Sharp; Damian C Crowther; Maki Onda; Jan Johansson; David A Lomas
Journal: Eur J Biochem Date: 2004-08

Tissue plasminogen activator, neuroserpin, and seizures.

1. Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen. Role in the regulation of fibrinolysis and identification as histidine-rich glycoprotein.

2. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

3. Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy.

4. Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.

Review 5. New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system.

6. Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.

7. Extracellular proteolysis in the adult murine brain.

8. Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator.

9. Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

10. Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.