| Literature DB >> 16151171 |
S Sitthisak1, K Howieson, C Amezola, R K Jayaswal.
Abstract
A multicopper oxidase gene from Staphylococcus aureus was cloned and overexpressed. Purified recombinant multicopper oxidase oxidized the substrate 3,3'-dimethoxybenzidine in the presence of copper. Disruption of mco showed copper sensitivity and H(2)O(2) resistance, suggesting roles for mco in copper homeostasis and oxidative stress response. Northern blot analysis showed copper-induced mco transcription.Entities:
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Year: 2005 PMID: 16151171 PMCID: PMC1214694 DOI: 10.1128/AEM.71.9.5650-5653.2005
Source DB: PubMed Journal: Appl Environ Microbiol ISSN: 0099-2240 Impact factor: 4.792