Literature DB >> 16151049

Psychostimulants, L-type calcium channels, kinases, and phosphatases.

Anjali M Rajadhyaksha1, Barry E Kosofsky.   

Abstract

There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression. Here the authors will review recent progress in our understanding of L-type Ca2+ channel-activated signal transduction pathways that contribute to molecular neuroadaptations evident following acute and chronic exposures to psychostimulants.

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Year:  2005        PMID： 16151049      PMCID： PMC2706980          DOI： 10.1177/1073858405278236

Source DB:  PubMed          Journal:  Neuroscientist        ISSN： 1073-8584            Impact factor:   7.519


  62 in total

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  14 in total

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