OBJECTIVE: This study was undertaken to evaluate whether the proximity of infection of the chorion/amnion and fetal vessels affects neonatal outcomes. STUDY DESIGN: We examined all (n=2012) infants admitted to the British Columbia's Children's Hospital Neonatal Intensive Care Unit, from January 1996 to October 1997. We included infants with a placental examination (n=1296), and stratified those with histologic chorioamnionitis into cases displaying a maternal inflammatory response only and cases also displaying a fetal inflammatory response (funisitis and/or fetal surface vessel angiitis). RESULTS: Histologic evidence of chorioamnionitis was present in 31% of placentas. Of those, 38% exhibited maternal inflammation only, whereas 62% also exhibited fetal inflammation. Neonatal mortality (9.2% vs 7.2%), morbidity, and resource use were significantly (P < .05) higher when fetal inflammation was present compared with when only maternal inflammation was present. CONCLUSION: Chorioamnionitis with a fetal inflammatory response is associated with higher neonatal mortality, morbidity, and resource use than when only a maternal inflammatory response is present.
OBJECTIVE: This study was undertaken to evaluate whether the proximity of infection of the chorion/amnion and fetal vessels affects neonatal outcomes. STUDY DESIGN: We examined all (n=2012) infants admitted to the British Columbia's Children's Hospital Neonatal Intensive Care Unit, from January 1996 to October 1997. We included infants with a placental examination (n=1296), and stratified those with histologic chorioamnionitis into cases displaying a maternal inflammatory response only and cases also displaying a fetal inflammatory response (funisitis and/or fetal surface vessel angiitis). RESULTS: Histologic evidence of chorioamnionitis was present in 31% of placentas. Of those, 38% exhibited maternal inflammation only, whereas 62% also exhibited fetal inflammation. Neonatal mortality (9.2% vs 7.2%), morbidity, and resource use were significantly (P < .05) higher when fetal inflammation was present compared with when only maternal inflammation was present. CONCLUSION:Chorioamnionitis with a fetal inflammatory response is associated with higher neonatal mortality, morbidity, and resource use than when only a maternal inflammatory response is present.
Authors: Kristin Palmsten; Katharine K Nelson; Louise C Laurent; Soojin Park; Christina D Chambers; Mana M Parast Journal: Placenta Date: 2018-06-06 Impact factor: 3.481
Authors: Erin M Fricke; Timothy G Elgin; Huiyu Gong; Jeff Reese; Katherine N Gibson-Corley; Robert M Weiss; Kathy Zimmerman; Noelle C Bowdler; Karen M Kalantera; David A Mills; Mark A Underwood; Steven J McElroy Journal: Am J Reprod Immunol Date: 2018-01-25 Impact factor: 3.886
Authors: Megan E McCarthy; Catalin S Buhimschi; John T Hardy; Antonette T Dulay; Christine A Laky; Mert-Ozan Bahtyiar; Ramesha Papanna; Guomao Zhao; Irina A Buhimschi Journal: Placenta Date: 2017-12-24 Impact factor: 3.481
Authors: Ariel A Salas; Ona M Faye-Petersen; Brian Sims; Myriam Peralta-Carcelen; Stephanie D Reilly; Gerald McGwin; Waldemar A Carlo; Namasivayam Ambalavanan Journal: J Pediatr Date: 2013-05-08 Impact factor: 4.406