Literature DB >> 1614821

Neurotransmitters inhibit the omega-conotoxin-sensitive component of Ca current in neuroblastoma x glioma hybrid (NG 108-15) cells, not the nifedipine-sensitive component.

M P Caulfield1, J Robbins, D A Brown.   

Abstract

Voltage-dependent calcium currents (ICa) in NG 108-15 cells consisted of three pharmacologically distinct components: a transient low-voltage-activated (LVA) current, sensitive to Ni2+; a high-voltage-activated (HVA) current sensitive to the dihydropyridine antagonist, nifedipine and a HVA current sensitive to omega-conotoxin GVIA (CgTx). The voltage sensitivities and decay kinetics of the two HVA currents were indistinguishable. The neurotransmitters acetylcholine (ACh) and noradrenaline inhibited ICa. This inhibition was not occluded by Ni2+ or nifedipine, but was abolished by CgTx. It is therefore concluded that the neurotransmitter-sensitive component of ICa is restricted to that component of HVA current inhibitable by omega-conotoxin.

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Year:  1992        PMID： 1614821     DOI： 10.1007/bf00374623

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  28 in total

1.  Evidence for multiple types of Ca2+ channels in acutely isolated hippocampal CA3 neurones of the guinea-pig.

Authors:  D J Mogul; A P Fox
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

2.  Pharmacological characterization of voltage-dependent calcium currents in rat hippocampal neurons.

Authors:  M Toselli; V Taglietti
Journal:  Neurosci Lett       Date:  1990-04-20       Impact factor: 3.046

3.  Reversible uncoupling of inactivation in N-type calcium channels.

Authors:  M R Plummer; P Hess
Journal:  Nature       Date:  1991-06-20       Impact factor: 49.962

4.  Calcium channels in vertebrate neurons. Experiments on a neuroblastoma hybrid model.

Authors:  D A Brown; R J Docherty; I McFadzean
Journal:  Ann N Y Acad Sci       Date:  1989       Impact factor: 5.691

5.  Alpha-adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating.

Authors:  D Lipscombe; S Kongsamut; R W Tsien
Journal:  Nature       Date:  1989-08-24       Impact factor: 49.962

6.  Voltage-dependent GABA-induced modulation of calcium currents in chick sensory neurons.

Authors:  F Grassi; H D Lux
Journal:  Neurosci Lett       Date:  1989-10-23       Impact factor: 3.046

7.  Pharmacology of the putative M4 muscarinic receptor mediating Ca-current inhibition in neuroblastoma x glioma hybrid (NG 108-15) cells.

Authors:  M P Caulfield; D A Brown
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

8.  Noradrenaline-Induced Inhibition of Voltage-Sensitive Calcium Currents in NG108-15 Hybrid Cells.

Authors:  R. J. Docherty; I. McFadzean
Journal:  Eur J Neurosci       Date:  1989-03       Impact factor: 3.386

9.  Selective coupling of different muscarinic acetylcholine receptors to neuronal calcium currents in DNA-transfected cells.

Authors:  H Higashida; M Hashii; K Fukuda; M P Caulfield; S Numa; D A Brown
Journal:  Proc Biol Sci       Date:  1990-10-22       Impact factor: 5.349

10.  Calcium currents in bullfrog sympathetic neurons. I. Activation kinetics and pharmacology.

Authors:  S W Jones; T N Marks
Journal:  J Gen Physiol       Date:  1989-07       Impact factor: 4.086
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  10 in total

1.  The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin.

Authors:  M A Wilk-Blaszczak; W D Singer; T Quill; B Miller; J A Frost; P C Sternweis; F Belardetti
Journal:  J Neurosci       Date:  1997-06-01       Impact factor: 6.167

2.  Depression of high-threshold calcium currents by activation of human D2 (short) dopamine receptors expressed in differentiated NG108-15 cells.

Authors:  G R Seabrook; G McAllister; M R Knowles; J Myers; H Sinclair; S Patel; S B Freedman; J A Kemp
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

3.  Ca2+ influx through voltage-gated Ca2+ channels regulates 5-HT3 receptor channel desensitization in rat glioma x mouse neuroblastoma hybrid NG108-15 cells.

Authors:  S Jones; J L Yakel
Journal:  J Physiol       Date:  1998-07-15       Impact factor: 5.182

4.  M2 muscarinic receptor-mediated inhibition of the Ca2+ current in rat magnocellular cholinergic basal forebrain neurones.

Authors:  T G Allen; D A Brown
Journal:  J Physiol       Date:  1993-07       Impact factor: 5.182

5.  Phosphorylation- and voltage-dependent inhibition of neuronal calcium currents by activation of human D2(short) dopamine receptors.

Authors:  N A Brown; G R Seabrook
Journal:  Br J Pharmacol       Date:  1995-06       Impact factor: 8.739

6.  Muscarinic (M1) receptor-mediated inhibition of K(+)-evoked [3H]-noradrenaline release from human neuroblastoma (SH-SY5Y) cells via inhibition of L- and N-type Ca2+ channels.

Authors:  R L McDonald; P F Vaughan; C Peers
Journal:  Br J Pharmacol       Date:  1994-10       Impact factor: 8.739

7.  Enhancement of an L-type calcium current in AtT-20 cells; a novel effect of the m4 muscarinic receptor.

Authors:  K E Pemberton; S V Jones
Journal:  Pflugers Arch       Date:  1995-03       Impact factor: 3.657

8.  Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts.

Authors:  M A Grassie; G Milligan
Journal:  Biochem J       Date:  1995-03-01       Impact factor: 3.857

9.  Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.

Authors:  Balapal S Basavarajappa
Journal:  Curr Neuropharmacol       Date:  2007       Impact factor: 7.363

10.  Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth.

Authors:  Yin Yin; Lin Qu; Dicong Zhu; Yang Wu; Xin Zhou
Journal:  Transl Pediatr       Date:  2021-06
  10 in total

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