Literature DB >> 16148013

Tetraparesis associated with colchicine is probably due to inhibition by verapamil of the P-glycoprotein efflux pump in the blood-brain barrier.

Uwe Tröger1, Hartmut Lins, Jean-M Scherrmann, Claus-Werner Wallesch, Stefanie M Bode-Böger.   

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Year:  2005        PMID： 16148013      PMCID： PMC1215555          DOI： 10.1136/bmj.38568.639688.F7

Source DB:  PubMed          Journal:  BMJ        ISSN： 0959-8138


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  4 in total

1.  Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.

Authors:  C Pauli-Magnus; O von Richter; O Burk; A Ziegler; T Mettang; M Eichelbaum; M F Fromm
Journal:  J Pharmacol Exp Ther       Date:  2000-05       Impact factor: 4.030

2.  Role of P-170 glycoprotein in colchicine brain uptake.

Authors:  N Drion; P Risede; N Cholet; C Chanez; J M Scherrmann
Journal:  J Neurosci Res       Date:  1997-07-01       Impact factor: 4.164

3.  Pharmacokinetics and absolute bioavailability of colchicine after i.v. and oral administration in healthy human volunteers and elderly subjects.

Authors:  M Rochdi; A Sabouraud; C Girre; R Venet; J M Scherrmann
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

4.  Colchicine myopathy and neuropathy.

Authors:  R W Kuncl; G Duncan; D Watson; K Alderson; M A Rogawski; M Peper
Journal:  N Engl J Med       Date:  1987-06-18       Impact factor: 91.245
  4 in total
  4 in total

Review 1.  Clinical Implications of P-Glycoprotein Modulation in Drug-Drug Interactions.

Authors:  Marie Lund; Tonny Studsgaard Petersen; Kim Peder Dalhoff
Journal:  Drugs       Date:  2017-05       Impact factor: 9.546

2.  Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein.

Authors:  Arik Dahan; Gordon L Amidon
Journal:  Pharm Res       Date:  2008-12-02       Impact factor: 4.200

Review 3.  Colchicine: its mechanism of action and efficacy in crystal-induced inflammation.

Authors:  George Nuki
Journal:  Curr Rheumatol Rep       Date:  2008-07       Impact factor: 4.592

Review 4.  Drug interactions at the blood-brain barrier: fact or fantasy?

Authors:  Sara Eyal; Peng Hsiao; Jashvant D Unadkat
Journal:  Pharmacol Ther       Date:  2009-04-22       Impact factor: 13.400
  4 in total

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