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Literature DB >> 16146793

TGF-beta and CD4+CD25+ regulatory T cells.

Abstract

TGF-beta and CD4+CD25+ regulatory T cells (Treg) both play an important role in the control of immune responses and the maintenance of immune homeostasis. The mechanism of suppression induced by Treg and the factors which regulate Treg function and number, have only begun to be elucidated. TGF-beta seems to act as an effector cytokine involved in the immunosuppressive function of Treg in vitro and in vivo, although its origin and mechanism of action remains to be defined. In addition, TGF-beta signaling in peripheral Treg seems to be essential for the regulation of peripheral Treg numbers and for their immunosuppressive function in vivo. This review will focus on the role of TGF-beta for the generation and expansion of CD4+CD25+ Treg, as well as for their immunosuppressive function in vitro and in vivo.

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Year: 2006 PMID： 16146793 DOI： 10.2741/1859

Source DB: PubMed Journal: Front Biosci ISSN： 1093-4715

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Cited

18 in total

1. Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase.

Authors: Sourojit Bhowmick; Robert B Clark; Stefan Brocke; Robert E Cone
Journal: Int Immunol Date: 2011-01-27 Impact factor: 4.823

2. Hetero-Polysaccharides Secreted from Dunaliella salina Exhibit Immunomodulatory Activity Against Peripheral Blood Mononuclear Cells and RAW 264.7 Macrophages.

Authors: Mehendi Goyal; Manoj Baranwal; Satyendra Kumar Pandey; Mondem Sudhakara Reddy
Journal: Indian J Microbiol Date: 2019-08-23 Impact factor: 2.461

Review 3. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.

Authors: Taku Okazaki; Shunsuke Chikuma; Yoshiko Iwai; Sidonia Fagarasan; Tasuku Honjo
Journal: Nat Immunol Date: 2013-12 Impact factor: 25.606

4. The sympathetic nervous system modulates CD4(+)FoxP3(+) regulatory T cells via a TGF-beta-dependent mechanism.

Authors: Sourojit Bhowmick; Anurag Singh; Richard A Flavell; Robert B Clark; James O'Rourke; Robert E Cone
Journal: J Leukoc Biol Date: 2009-09-09 Impact factor: 4.962

5. Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs.

Authors: Stefan Lüth; Samuel Huber; Christoph Schramm; Thorsten Buch; Stefan Zander; Christine Stadelmann; Wolfgang Brück; David C Wraith; Johannes Herkel; Ansgar W Lohse
Journal: J Clin Invest Date: 2008-10 Impact factor: 14.808

6. Phosphatidylinositol-3-kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity.

Authors: Valentina Di Caro; Antonella D'Anneo; Brett Phillips; Carl Engman; Jo Harnaha; Massimo Trucco; Nick Giannoukakis
Journal: Immunol Res Date: 2011-08 Impact factor: 2.829

TGF-beta and CD4+CD25+ regulatory T cells.

1. Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase.

2. Hetero-Polysaccharides Secreted from Dunaliella salina Exhibit Immunomodulatory Activity Against Peripheral Blood Mononuclear Cells and RAW 264.7 Macrophages.

Review 3. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.

4. The sympathetic nervous system modulates CD4(+)FoxP3(+) regulatory T cells via a TGF-beta-dependent mechanism.

5. Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs.

6. Phosphatidylinositol-3-kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity.

7. Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis.

8. Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis.

Review 9. Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review.

Review 10. Protease-activated receptors and prostaglandins in inflammatory lung disease.