Literature DB >> 16146382

Expedient synthesis of potent cannabinoid receptor agonist (-)-CP55,940.

Noriaki Itagaki1, Tsutomu Sugahara, Yoshiharu Iwabuchi.   

Abstract

[reaction: see text] A stereocontrolled synthesis of (-)-CP55,940, a potent cannabinoid receptor agonist, has been attained using a novel aldolization/retro-aldolization interconversion strategy, in which a temporarily generated chiral aldol motif plays essential roles.

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Year:  2005        PMID: 16146382     DOI: 10.1021/ol051570c

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.

Authors:  John W Huffman; Seon A Hepburn; Patricia H Reggio; Dow P Hurst; Jenny L Wiley; Billy R Martin
Journal:  Bioorg Med Chem       Date:  2010-06-22       Impact factor: 3.641

2.  Location, structure, and dynamics of the synthetic cannabinoid ligand CP-55,940 in lipid bilayers.

Authors:  Tomohiro Kimura; Kejun Cheng; Kenner C Rice; Klaus Gawrisch
Journal:  Biophys J       Date:  2009-06-17       Impact factor: 4.033

  2 in total

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