Literature DB >> 16146360

An improved synthesis of the "miracle nutrient" coenzyme Q10.

Bruce H Lipshutz1, Asher Lower, Volker Berl, Karin Schein, Frank Wetterich.   

Abstract

[reaction: see text] A new route to the key coupling partner, chloromethylated CoQ0 (1), allows for direct formation of CoQ10 (3) via nickel-catalyzed cross-coupling with the side chain in the form of an in situ-derived vinyl alane (2).

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Year:  2005        PMID： 16146360     DOI： 10.1021/ol051329y

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

Review 1.  CoQ10 a super-vitamin: review on application and biosynthesis.

Authors:  Shraddha Shukla; Kashyap Kumar Dubey
Journal:  3 Biotech       Date:  2018-05-09       Impact factor: 2.406

2.  Total synthesis of piericidin A1. Application of a modified Negishi carboalumination-nickel-catalyzed cross-coupling.

Authors:  Bruce H Lipshutz; Benjamin Amorelli
Journal:  J Am Chem Soc       Date:  2009-02-04       Impact factor: 15.419

3.  Propargylation of CoQ0 through the Redox Chain Reaction.

Authors:  Robert Pawlowski; Maciej Stodulski; Jacek Mlynarski
Journal:  J Org Chem       Date:  2021-12-21       Impact factor: 4.354

4.  A non-canonical vitamin K cycle is a potent ferroptosis suppressor.

Authors:  Eikan Mishima; Junya Ito; Zijun Wu; Toshitaka Nakamura; Adam Wahida; Sebastian Doll; Wulf Tonnus; Palina Nepachalovich; Elke Eggenhofer; Maceler Aldrovandi; Bernhard Henkelmann; Ken-Ichi Yamada; Jonas Wanninger; Omkar Zilka; Emiko Sato; Regina Feederle; Daniela Hass; Adriano Maida; André Santos Dias Mourão; Andreas Linkermann; Edward K Geissler; Kiyotaka Nakagawa; Takaaki Abe; Maria Fedorova; Bettina Proneth; Derek A Pratt; Marcus Conrad
Journal:  Nature       Date:  2022-08-03       Impact factor: 69.504

5.  Preparation of Key Intermediates for the Syntheses of Coenzyme Q10 and Derivatives by Cross-Metathesis Reactions.

Authors:  Trang Nguyen; Hung Mac; Phong Pham
Journal:  Molecules       Date:  2020-01-21       Impact factor: 4.411
  5 in total

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