Li-Jian Tao1, Jun Zhang, Gao-Yun Hu. 1. Department of Nephrology, Xiangya Hospital, School of Pharmaceutical Science, Central South University, Changsha 410008, China. Taolj@xysm.net
Abstract
OBJECTIVE: To explore the curative effects of 1-(3-fluorophenyl)-5-methyl-2- (1H)-pyridone (FMP) on renal fibrosis in rats. METHODS: The effects of FMP on the cell proliferation and Fn secretion were measured by methyl thiazolyl tetrazolium and enzyme-linked immunoabsorbent assay, respectively. RESULTS: FMP obviously inhibited the proliferation and Fn secretion in rat renal fibroblast 48 hours after the treatment. FMP (1 000 microg/ml) obviously inhibited the proliferation of rat renal fibroblast 24 hours after the treatment. CONCLUSION: 1-(3-Fluorophenyl) -5-methyl-2-(1H)-pyridone can obviously inhibit the proliferation of rat renal fibroblast, which may be effective for renal interstitial fibrosis prevention and treatment.
OBJECTIVE: To explore the curative effects of 1-(3-fluorophenyl)-5-methyl-2- (1H)-pyridone (FMP) on renal fibrosis in rats. METHODS: The effects of FMP on the cell proliferation and Fn secretion were measured by methyl thiazolyl tetrazolium and enzyme-linked immunoabsorbent assay, respectively. RESULTS:FMP obviously inhibited the proliferation and Fn secretion in rat renal fibroblast 48 hours after the treatment. FMP (1 000 microg/ml) obviously inhibited the proliferation of rat renal fibroblast 24 hours after the treatment. CONCLUSION:1-(3-Fluorophenyl) -5-methyl-2-(1H)-pyridone can obviously inhibit the proliferation of rat renal fibroblast, which may be effective for renal interstitial fibrosis prevention and treatment.