| Literature DB >> 16144384 |
Chao Li1, Marco Curreli, Henry Lin, Bo Lei, F N Ishikawa, Ram Datar, Richard J Cote, Mark E Thompson, Chongwu Zhou.
Abstract
We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16144384 DOI： 10.1021/ja053761g
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419