BACKGROUND: We assessed the characteristics of symptomatic gastroesophageal reflux disease (sGERD), defined as the presence of symptoms, but no endoscopic findings of reflux esophagitis, in Japanese. METHODS: Sixty-three patients were diagnosed with sGERD, and underwent 24-h esophagogastric pH monitoring (32 men; mean age, 50.5 years). Patients were classified into the following three groups : reflux group (group R), minor reflux group (group MR), and a no-reflux group (group N) by the percentage of time at pH below 4 (group R, 4.0% or more; group MR, 2.0%-3.9%; group N, 0-1.9%). Hiatal hernia was assessed based on the Anatomy-Function-Pathology (AFP) classification, and the shape of the cardia was assessed based on valve factors (V0-V3). RESULTS: There were 13 patients (21%) in group R, 17 (27%) in group MR, and 33 (52%) in group N. Hiatal hernia was present in 11 patients (85%) in group R, 14 (82%) in group MR, and 22 (67%) in group N. Patients grouped according to presence of V2/V3 (chalasia) accounted for 100% of those in group R, 71% of those in group MR and 70% of those in group N. Hiatal hernia was present in 10 (91%), 10 (83%), and 6 patients (86%) who had 50 or more episodes of esophageal acid reflux per day in group R, group MR, and group N, respectively. CONCLUSIONS: Reflux (percentage of time below pH 4, 4%) was seen in only about 20% of the patients with sGERD, and this percentage of patients with reflux was lower compared to the data reported from the United States and Europe. The percentage of patients who had a hiatal hernia or chalasia was high in all these groups, and this seemed to be a characteristic cause of sGERD in Japanese.
BACKGROUND: We assessed the characteristics of symptomatic gastroesophageal reflux disease (sGERD), defined as the presence of symptoms, but no endoscopic findings of reflux esophagitis, in Japanese. METHODS: Sixty-three patients were diagnosed with sGERD, and underwent 24-h esophagogastric pH monitoring (32 men; mean age, 50.5 years). Patients were classified into the following three groups : reflux group (group R), minor reflux group (group MR), and a no-reflux group (group N) by the percentage of time at pH below 4 (group R, 4.0% or more; group MR, 2.0%-3.9%; group N, 0-1.9%). Hiatal hernia was assessed based on the Anatomy-Function-Pathology (AFP) classification, and the shape of the cardia was assessed based on valve factors (V0-V3). RESULTS: There were 13 patients (21%) in group R, 17 (27%) in group MR, and 33 (52%) in group N. Hiatal hernia was present in 11 patients (85%) in group R, 14 (82%) in group MR, and 22 (67%) in group N. Patients grouped according to presence of V2/V3 (chalasia) accounted for 100% of those in group R, 71% of those in group MR and 70% of those in group N. Hiatal hernia was present in 10 (91%), 10 (83%), and 6 patients (86%) who had 50 or more episodes of esophageal acid reflux per day in group R, group MR, and group N, respectively. CONCLUSIONS: Reflux (percentage of time below pH 4, 4%) was seen in only about 20% of the patients with sGERD, and this percentage of patients with reflux was lower compared to the data reported from the United States and Europe. The percentage of patients who had a hiatal hernia or chalasia was high in all these groups, and this seemed to be a characteristic cause of sGERD in Japanese.
Authors: R Carlsson; J Dent; R Watts; S Riley; R Sheikh; J Hatlebakk; K Haug; G de Groot; A van Oudvorst; A Dalväg; O Junghard; I Wiklund Journal: Eur J Gastroenterol Hepatol Date: 1998-02 Impact factor: 2.566
Authors: T Lind; T Havelund; R Carlsson; O Anker-Hansen; H Glise; H Hernqvist; O Junghard; K Lauritsen; L Lundell; S A Pedersen; A Stubberöd Journal: Scand J Gastroenterol Date: 1997-10 Impact factor: 2.423
Authors: B E Schenk; E J Kuipers; E C Klinkenberg-Knol; H P Festen; E H Jansen; H A Tuynman; M Schrijver; L A Dieleman; S G Meuwissen Journal: Am J Gastroenterol Date: 1997-11 Impact factor: 10.864