OBJECTIVE: To describe families with multiple members affected with Kawasaki syndrome (KS) to increase awareness of the familial occurrence of KS among practitioners who care for these patients. DESIGN: Retrospective review of medical records at 2 medical centers and data collection from remote KS families who contacted the KS Research Program at the University of California, San Diego. RESULTS: Eighteen families with multiple affected members were identified. There were 9 families with 2 affected siblings. In San Diego, 3 (0.7%) of 424 KS families had sibling cases. Nine families were identified with KS in 2 generations or in multiple affected members, yielding a total of 24 KS-affected children. No clear pattern of inheritance could be deduced from these pedigrees, and it is likely that multiple polymorphic alleles influence KS susceptibility. CONCLUSION: Physicians should counsel affected families and make them aware of the potential increased risk of KS among family members.
OBJECTIVE: To describe families with multiple members affected with Kawasaki syndrome (KS) to increase awareness of the familial occurrence of KS among practitioners who care for these patients. DESIGN: Retrospective review of medical records at 2 medical centers and data collection from remote KS families who contacted the KS Research Program at the University of California, San Diego. RESULTS: Eighteen families with multiple affected members were identified. There were 9 families with 2 affected siblings. In San Diego, 3 (0.7%) of 424 KS families had sibling cases. Nine families were identified with KS in 2 generations or in multiple affected members, yielding a total of 24 KS-affected children. No clear pattern of inheritance could be deduced from these pedigrees, and it is likely that multiple polymorphic alleles influence KS susceptibility. CONCLUSION: Physicians should counsel affected families and make them aware of the potential increased risk of KS among family members.
Authors: Robert C Holman; Aaron T Curns; Ermias D Belay; Claudia A Steiner; Paul V Effler; Krista L Yorita; Jill Miyamura; Susan Forbes; Lawrence B Schonberger; Marian Melish Journal: Pediatr Infect Dis J Date: 2005-05 Impact factor: 2.129
Authors: C T Gordon; S Jimenez-Fernandez; L B Daniels; A M Kahn; M Tarsa; T Matsubara; C Shimizu; J C Burns; J B Gordon Journal: BJOG Date: 2014-03-06 Impact factor: 6.531
Authors: David Burgner; Sonia Davila; Willemijn B Breunis; Sarah B Ng; Yi Li; Carine Bonnard; Ling Ling; Victoria J Wright; Anbupalam Thalamuthu; Miranda Odam; Chisato Shimizu; Jane C Burns; Michael Levin; Taco W Kuijpers; Martin L Hibberd Journal: PLoS Genet Date: 2009-01-09 Impact factor: 5.917