| Literature DB >> 16143535 |
Herbert Kolodziej1, Anne Burmeister, Weronika Trun, Oliver A Radtke, Albrecht F Kiderlen, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Lai Yeap Foo.
Abstract
Some polyphenol-containing extracts (Pelargonium sidoides, Phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-O-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (iNOS, IL-1, IL-10, IL-12, IL-18, TNF-alpha, IFN-alpha/gamma) by RT-PCR. All extracts and compounds were capable of enhancing the iNOS and cytokine mRNA levels in parasitised cells when compared with those in non-infected conditions.Entities:
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Year: 2005 PMID： 16143535 DOI： 10.1016/j.bmc.2005.07.012
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641