| Literature DB >> 16143524 |
Evgueni L Piatnitski1, Matthew A J Duncton, Alexander S Kiselyov, Reeti Katoch-Rouse, Dan Sherman, Daniel L Milligan, Chris Balagtas, Wai C Wong, Joel Kawakami, Jacqueline F Doody.
Abstract
A novel class of 4-arylamino-phthalazin-1-yl-benzamides is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Several compounds display potent VEGFR-2 inhibitory activity with an IC50 as low as 0.078 microM in an HTRF enzymatic assay. These compounds are relatively selective against a small kinase panel.Entities:
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Year: 2005 PMID： 16143524 DOI： 10.1016/j.bmcl.2005.07.064
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823